How Much Sequencing Is Enough? Study Maps the Depth Limits of Hi-C Chromatin Maps
A systematic subsampling analysis of twelve Hi-C libraries reveals that different chromatin metrics need vastly different sequencing depths, with genome-average ...
Tag: chromatin structure
Chaperone protein guides histone H1 to its nucleosome target, study reveals
Single-molecule experiments show that linker histone H1, essential for compacting and silencing genes, can bind and slide along DNA but ...
Open Chromatin Is Not So Open: Active Genes Ride on Condensed Domains
New simulations reveal that euchromatin is mostly condensed into dense domains, with short active regulatory regions protruding on their surfaces ...
Life uses one language to activate genes, but many to silence them
Cells across the eukaryotic tree of life appear to rely on a remarkably ancient system for switching genes on, while ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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