ORC1: The Replication Gatekeeper Linking Genome Stability to Cancer
A new review in the Journal of Translational Medicine consolidates how the replication-initiation protein ORC1 safeguards genome stability and why ...
Tag: chromatin remodeling
Chromatin Loss Rewires Kidney Cancer Mitochondria, and an Old Drug Can Reverse It
A Nature Communications study shows that loss of the SWI/SNF subunit SMARCD1 drives clear cell renal cell carcinoma through a ...
Genes and Epigenetics Converge to Explain Sudden Cardiac Death Without Family History
A new review maps how common genetic variants, insertion/deletion polymorphisms, microRNAs, DNA methylation and histone modifications together shape the risk ...
Cellular Program Behind Aging May Also Shape Embryos, CHARGE Syndrome Review Suggests
A new review proposes that misregulation of developmental senescence, a transient embryonic cell-arrest program, may contribute to the congenital defects ...
Cucumber Genome Atlas Maps Sex Determination Networks
A new genome-wide atlas maps line-specific molecular networks in cucumber sex determination, offering a candidate resource for precision breeding.
Chromatin Remodeler INO80 Emerges as Master Gatekeeper of Lymphatic Vessel Development
A new study identifies the chromatin remodeler INO80 as a critical regulator of ETS transcription factor programs required for embryonic ...
AI Reads the 3D Architecture of Chromatin to Predict Stem Cell Aging
A compact convolutional neural network called ChromAgeNet can distinguish young from aged hematopoietic stem cells using 3D DAPI-stained microscopy images ...
WIND1 Rewrites Plant Cell Fate by Flipping a Single Histone Switch Both Ways
A new commentary highlights how the transcription factor WIND1 simultaneously promotes acetylation and deacetylation of histone H3 lysine 27, coordinating ...
ATRX partners with 9-1-1 and CST to protect genome replication and telomeres
Every time a human cell divides, it must copy roughly six billion letters of DNA—a feat accomplished by molecular machines ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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