AI Decodes the Hidden Grammar of the Genome’s Master Organizer CTCF
A new computational framework called DeCTCF uses AI-predicted epigenomic features to sort more than 236,000 CTCF binding sites into 20 ...
Tag: chromatin architecture
New Nanoscale Genome Mapping Tool Pinpoints Causal Autoimmunity Variants
An Oxford-developed single-allele chromatin mapping platform called MCCv identifies causal noncoding variants in autoimmune disease and reveals that a neo-CTCF ...
How HPV Reshapes the 3D Genome to Lock Cervical Cancer Into Resistant States
A new review argues that host chromatin architecture and three-dimensional genome rewiring, not just HPV oncoproteins, stabilize malignant states and ...
Hidden Genome Folds Silence Two Tumor-Suppressing Genes in Aggressive Breast Cancer
Researchers have discovered that DNA methylation evicts the architectural protein CTCF from the HOXD locus, collapsing a chromatin loop that ...
Diseased Kidneys Age Faster at the Cellular Level, Single-Cell Epigenome Atlas Reveals
A cross-species single-cell epigenome atlas shows that kidney disease accelerates epigenetic aging most dramatically in tubular epithelial cells, which lose ...
Gene Activity Comes in Bursts: Epigenetics Reshapes the Picture of Transcriptional Noise
A new review argues that transcription occurs in multi-scale bursts shaped by DNA methylation, histone variants, modifications and enhancer looping, ...
African swine fever virus reshapes host genome architecture within hours of infection
New research shows that African swine fever virus extensively reorganizes host chromatin architecture and RNA polymerase II activity within hours ...
AI Reads the 3D Architecture of Chromatin to Predict Stem Cell Aging
A compact convolutional neural network called ChromAgeNet can distinguish young from aged hematopoietic stem cells using 3D DAPI-stained microscopy images ...
Spatial Hi-C Maps 3D Genome Folding Directly Inside Brain Tissue
A new microfluidic method called spatial Hi-C maps genome-wide 3D chromatin folding directly within intact brain tissue sections, revealing lobule-specific ...
New Method Maps Both Chromatin Access and 3D Folding in Intact Tissues
A new method called Spatial-ATAC-Hi-C simultaneously maps chromatin accessibility and three-dimensional genome organization in intact tissue sections, as demonstrated on ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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