AI Decodes the Hidden Grammar of the Genome’s Master Organizer CTCF
A new computational framework called DeCTCF uses AI-predicted epigenomic features to sort more than 236,000 CTCF binding sites into 20 ...
Tag: ChIP-seq
ZBED6 Loss Fuels Pathological Heart Enlargement Through a Newly Mapped Gene Switch
New research in PLOS Genetics identifies the ZBED6–MEOX1–ERK1/2 axis as a key regulator of pathological cardiac hypertrophy through impaired autophagy.
High Blood Sugar Rewrites Pancreatic Cell Chemistry, Driving Stress Granule Buildup in Diabetes
New research shows that diabetes elevates the histone mark H3K4me1 in pancreatic acinar cells, driving stress granule formation under high ...
Oocyte Gene Figla May Steer Ovarian Reserve Formation Through Ywhab, Mouse Study Suggests
A new mouse and cell study identifies Ywhab as a candidate downstream target of the oocyte transcription factor Figla during ...
Hidden DNA Rings and a Rogue Gene Reveal Ovarian Cancer’s Adaptive Defense
A new study links HDAC inhibitor treatment to remodeling of extrachromosomal circular DNA in ovarian cancer and identifies LMO2 as ...
How a Shifting Cast of Transcription Factors Rewires Androgen Signaling in the Aging Brain
New research shows that Alzheimer's disease disrupts androgen receptor signaling in the male brain by dismantling the collaborative transcription factor ...
AI Agent Learns Expert Rules for Chromatin Data Analysis
A new Genome Biology study introduces ChromSkills, a curated library of expert-encoded Skills that makes AI agents consistent, stable and ...
Histone Chaperone NAP1L1 Keeps Gene Expression Steady in Stem Cells
A systematic screen combining single-cell RNA sequencing with ChIP-seq data has identified the histone chaperone NAP1L1 as a stabilizer of ...
New R Package ChIPSP Maps Gene Regulation in 3D, Revealing Hidden Cancer Targets
Researchers have developed ChIPSP, an R package that combines ChIP-seq with Hi-C chromatin loops to identify transcription factor target genes ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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