Study Maps Focused Transcription Factor Binding in Human Cells
Researchers identified highly focused transcription factor binding sites in human cells, revealing that these narrow regions are essential for maintaining ...
Tag: ChIP-seq
Super-Resolution Imaging and Deep Learning Accurately Map Subcellular Epigenetic Reorganization
An image-based epigenetic profiling framework combining high-speed super-resolution microscopy with deep learning accurately classified cellular epigenetic states and uncovered chromatin ...
WDR-5 Regulates Embryonic Gene Expression Independently of H3K4 Methylation in Worms
A study in Caenorhabditis elegans reveals that the scaffolding protein WDR-5 directs extensive embryonic gene transcription through mechanisms independent of ...
Promoter-Proximal Receptor Binding Directs Hierarchical Vitamin D Gene Activation
Time-resolved mapping in human monocytes reveals that early promoter-proximal vitamin D receptor binding establishes core gene activation before distal enhancers ...
Ancient Alu Elements Emerge as Dynamic Immune Enhancers in Human Monocytes
A reanalysis of chromatin data from human monocytes shows that Alu elements gain enhancer-associated histone marks during bacterial LPS stimulation, ...
Unliganded Thyroid Hormone Receptor Steers Early Neural Development Without Its Hormone
Human stem cell-derived neural progenitor cells reveal that unliganded thyroid hormone receptor maintains chromatin homeostasis through the NuRD complex and ...
Scientists Map the Hidden Genome-Wide Targets of a Key Inflammatory Switch in Leukemia
A new genome-wide study maps the binding landscape of the inflammatory regulator IκBζ in chronic lymphocytic leukemia, revealing a conserved ...
AI Decodes the Hidden Grammar of the Genome’s Master Organizer CTCF
A new computational framework called DeCTCF uses AI-predicted epigenomic features to sort more than 236,000 CTCF binding sites into 20 ...
ZBED6 Loss Fuels Pathological Heart Enlargement Through a Newly Mapped Gene Switch
New research in PLOS Genetics identifies the ZBED6–MEOX1–ERK1/2 axis as a key regulator of pathological cardiac hypertrophy through impaired autophagy.
High Blood Sugar Rewrites Pancreatic Cell Chemistry, Driving Stress Granule Buildup in Diabetes
New research shows that diabetes elevates the histone mark H3K4me1 in pancreatic acinar cells, driving stress granule formation under high ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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