Quinoline scaffolds drive new wave of antiprotozoal drug discovery
The burden of protozoan disease is not evenly distributed across the globe, and this asymmetry shapes nearly every aspect of ...
Tag: Chagas disease
Proline Analogues Expose a Metabolic Weak Spot in the Chagas Disease Parasite
Trypanosoma cruzi, the single-celled parasite behind Chagas disease, has long frustrated drug developers... One of the more striking aspects of ...
Metabolomic profiling for the identification of drug targets in trypanosomes
Deep inside the metabolic machinery of two of the world's most neglected killers, a quiet revolution in drug discovery is ...
Cryo-EM snapshots expose the molecular machine that keeps deadly tropical parasites alive
Researchers at the University of Liège and Rockefeller University have captured near-atomic-resolution cryo-EM structures of the trans-spliceosome, the essential RNA-processing ...
Decade-Long Study Shows Secondary Chagas Bug Carries Surprisingly Little Parasite After Main Vector’s Removal
A ten-year surveillance program in the Argentine Chaco found that the secondary Chagas vector Triatoma sordida carries very low Trypanosoma ...
Chagas Parasite Keeps Its Gene Expression Playbook Across Strains, Study Finds
A large-scale reanalysis of 86 RNA-seq libraries shows that the developmental gene expression programs of Trypanosoma cruzi are largely conserved ...
Dark-Winged Chagas Bug Clusters in Rural Hotspots, Landscape Study Finds
A study of 901 Triatoma infestans bugs in Argentina shows that rare melanic individuals occur only in rural areas, form ...
Shorter Once-Daily Benznidazole Course Matches Standard Chagas Treatment With Fewer Side Effects
The TESEO trial shows that a 30-day once-daily benznidazole regimen is as effective as the 60-day standard treatment for chronic ...
Camouflage Confuses Chagas Bug Identification as DNA Steps In
Brazilian researchers show that Rhodnius neglectus bugs living in carnaúba palms can mimic the light brown coloration of Rhodnius nasutus, ...
Azo Compound Shows Promise Against Chagas and Leishmania Parasites
A synthetic azobenzenoid compound called CaCS2 shows broad-spectrum activity against Leishmania amazonensis and Trypanosoma cruzi with low human cell toxicity, ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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