Turning Cold Tumors Hot: Dual-Target Therapy Offers New Hope for Platinum-Resistant Ovarian Cancer
A new review outlines how combining PARP inhibitors with immune checkpoint inhibitors can convert immunologically cold ovarian tumors into hot ...
Tag: cGAS STING pathway
Mapping STING Mutations to Unlock Immunity and New Therapies
A comprehensive atlas of STING mutations consolidates genetic, structural, and clinical data to clarify how variants drive autoinflammation, immunodeficiency, and ...
cGAS-Deficient Mice Show Premature Aging Linked to LINE1 Derepression and Inflammation
A new study published in Nature Aging reports that mice lacking the enzyme cGAS develop signs of premature aging, accompanied ...
DNA Damage Response Pathways Inform New Cancer Immunotherapy Strategies
The DNA damage response (DDR) and the immune system may look like separate defense networks, but new research underscores how ...
Mitophagy dampens mitochondrial DNA–triggered cGAS-STING activation in autoimmune thyroiditis
Viral science news: Autoimmune thyroiditis has long puzzled researchers with how mitochondrial material sparks an inflammatory cascade that ultimately damages ...
Shining a Light on the Immune Response to Abnormal DNA
Recent advancements in the study of the innate immune response highlight the intricate mechanisms involved in detecting and responding to ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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