GeoCluster Preprocessing Framework Achieves 88.87-Meter Accuracy in Sigfox Device Localization
A hybrid preprocessing framework called GeoCluster reduces feature space by over 80 percent and achieves an 88.87-meter mean geodesic error ...
Tag: CFTR
Stress Granule Gene Signature Predicts Patient Outcomes in Esophageal Squamous Cell Carcinoma
An eight-gene stress granule signature stratifies survival outcomes and characterizes immune microenvironments in esophageal squamous cell carcinoma.
Redundant protein experiments fused into a ranking model for variant effects
Overlapping deep mutational scanning experiments were fused into a consensus variant soundness score that trained ESMRank, a sequence-based learning-to-rank model ...
Cystic Fibrosis Drug Ivacaftor Eases Lung Scarring in Mice by Rejuvenating Aging Air Sac Cells
A new mouse study shows the approved cystic fibrosis drug ivacaftor reduced pulmonary fibrosis by suppressing senescence in alveolar type ...
Cystic Fibrosis Macrophages Show Impaired Defense Against Resistant Lung Pathogen
New laboratory research shows that macrophages from people with cystic fibrosis are intrinsically impaired in controlling the virulent rough morphotype ...
Designer Amphotericin Derivatives Outperform Parent Drug as CFTR Surrogates in Airway Cells
Engineered amphotericin B derivatives with improved anion selectivity and reduced cholesterol binding outperform the parent compound as CFTR surrogates in ...
Chronic Lung Infection Surprisingly Sustains Gene Therapy Expression in Cystic Fibrosis Rat Lungs
New research in cystic fibrosis rats shows that chronic Pseudomonas aeruginosa lung infection does not hinder lentiviral vector gene transfer ...
Non-Tuberculous Mycobacteria and Bronchiectasis: A Growing Clinical Challenge
A new editorial in Frontiers in Tuberculosis examines the bidirectional relationship between non-tuberculous mycobacterial infection and bronchiectasis, highlighting genomic, immunological, ...
New Lipid Nanoparticles Supercharge CRISPR Delivery of Bulky Gene-Editing RNA
Researchers at the University of Toronto engineered an ionizable lipid, LC-1, that preserves its fusogenic structure when loaded with large ...
BEST4⁺ Intestinal Cells May Link Ion Transport to Viral Diarrhea
A review identifies BEST4⁺ intestinal epithelial cells as a possible link between pH sensing, ion transport, mucus hydration and diarrheal ...
-
Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
-
University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
-
Bee body mass, pathogens and local climate influence heat tolerance
-
Researchers record first-ever images and data of a shark experiencing a boat strike
-
Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
Embark on a thrilling journey of discovery with Scienmag.com—your ultimate source for cutting-edge breakthroughs. Immerse yourself in a world where curiosity knows no limits and tomorrow’s possibilities become today’s reality!