Chemotherapy Speeds One Aging Marker in Breast Cancer but Leaves Epigenetic Clocks Untouched
A head-to-head study of women with early breast cancer finds that T-cell p16INK4a and DNA methylation clocks are only weakly ...
Tag: Cellular senescence
Old Immunosuppressant Drug Found to Kill Aging Cells and Block Cancer
Researchers found that the immunosuppressant cyclosporine A selectively kills senescent cells by triggering endoplasmic reticulum stress and paraptosis-like death, preventing ...
Nanoparticles Emerge as a Powerful New Weapon Against Cellular Aging
A comprehensive review in Biogerontology argues that engineered nanoparticles could overcome the solubility, stability, and targeting limitations of senolytic drugs, ...
SIRT1 Silences Jumping Genes by Stabilizing Heterochromatin Complexes
Researchers report that SIRT1 suppresses L1 retrotransposon activity by recruiting and stabilizing the heterochromatin factors Lamin B1 and KAP1, an ...
How Chronic Stress May Accelerate Metabolic Ageing in Older Adults During Prolonged Crises
A Biogerontology Perspective argues that prolonged crises such as the war in Ukraine may biologically accelerate metabolic ageing in older ...
Scientists Chart a Common Roadmap to Bring Senescence Medicine Into the Clinic
A consensus statement from the SENESCENCE2030 network published in Nature Aging outlines a roadmap for turning cellular senescence research into ...
Senescent Kidney Cells Build Inflammatory Niches That Senolytics Can Dissolve
Researchers have mapped how senescent kidney cells attract immune cells into localized inflammatory niches and shown that senolytic treatments can ...
Metabolism Holds the Key to the Senescence Secretome
A Cell Research perspective argues that cellular metabolism acts as the licensing mechanism that determines the composition and intensity of ...
Machine learning defines cellular senescence signatures in lung adenocarcinoma
Cellular senescence has long been one of biology's most paradoxical phenomena. In healthy tissue, senescent cells—those that have permanently exited ...
Magnesium Emerges as Key Regulator of Mitochondria, Metabolism, and Aging
Magnesium has spent most of its scientific life backstage — the unglamorous electrolyte that keeps cellular housekeeping running while genes, ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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