Tag: cell plasticity

A new review proposes that mature tumor cells can dedifferentiate into cancer stem cells, acting as a non-genetic engine of ...

A systematic review finds that only 47 human studies address fusion between mesenchymal stem/stromal cells and tissue-specific cells, suggesting regenerative ...

A mouse organoid system shows that defined signals can separately initiate acinar-to-ductal conversion, sustain metaplastic expansion and promote partial redifferentiation ...

Researchers in Milan have identified MyD88 as a tumor cell-intrinsic switch that sustains a metastasis-competent, integrin-driven cell state in NRAS-mutant ...

Patient-derived organoid and xenograft models reveal that a collagen I-rich tumor matrix activates TGFβ signaling and LTBP2 expression, priming colorectal ...

A comprehensive review in Cell Death Discovery maps how the transcription factor Snail2 governs partial epithelial-mesenchymal transition, driving both embryonic ...

New research in C. elegans reveals that the gene lin-15A enables natural cell identity conversion by weakening chromatin-based safeguards rather ...

A new Nature Metabolism study shows that m6A methylation of messenger RNA actively controls the plasticity of pancreatic alpha cells, ...