Perforin Kills Cancer Cells Alone, Without Granzymes, Study Finds
New research shows the immune protein perforin can kill tumor cells on its own by triggering iron-dependent ferroptosis, even when ...
Tag: cell death
Scientists identify Tollip as a brake on plasma membrane repair
A new study identifies Tollip as a conserved negative regulator of ESCRT-III-mediated plasma membrane repair, showing that the protein balances ...
CISD2 knockdown suppresses gastric cancer and triggers ferroptosis
Knocking down CISD2 suppresses gastric cancer cell growth and induces ferroptosis through inhibition of the mTOR/SREBF1/SCD1 axis and GPX4 downregulation, ...
Periplocin Kills Osteosarcoma Cells by Driving Necroptosis and Pyroptosis
A new Biology Direct study shows that periplocin suppresses osteosarcoma cell proliferation and tumor growth in preclinical models by inducing ...
Glucose withdrawal triggers disulfidptosis-like cell death in diabetic retinopathy vessels
Researchers report that SLC7A11 upregulation in diabetic retinopathy vessels creates a glucose dependency that can be exploited to trigger disulfidptosis-like ...
Scientists discover a durable molecular fingerprint of ferroptosis in cells and blood
A reducing reagent-resistant dimer of transferrin receptor 1 emerges during lipid peroxidation and can be detected in tissues and blood-borne ...
Cell stress sensors ATF4 and ATF6 steer how lung cancer cells cope with glucose starvation
A new study shows that the stress sensors ATF4 and ATF6 coordinate transcriptional and metabolic responses to glucose deprivation in ...
Research report: Unraveling the iron grip: ferroptosis and its role in cardiovascular diseases
A new open-access review in Cell Biology and Toxicology examines how ferroptosis, an iron-dependent form of cell death, may contribute ...
DNA Sensor cGAS-STING Emerges as Double-Edged Driver of Acute Pancreatitis
A new review synthesizes evidence that the cGAS-STING DNA-sensing pathway both amplifies and restrains the inflammation and cell death that ...
Excess cysteine releases iron, overwhelming mitochondria and killing cells
A CRISPR screen and laboratory experiments show that excess cysteine releases iron from ferritin, damages mitochondria and triggers cell death.
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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