Ivermectin blunts cisplatin effects in oral cancer cells
A laboratory study found that ivermectin weakened cisplatin-associated cytotoxicity, apoptosis and S-phase arrest in HN9 oral cancer cells.
Tag: cell cycle arrest
Givinostat blocks colorectal cancer growth by silencing ADAM12 through miR-1938
New research shows the HDAC inhibitor givinostat stalls colorectal cancer growth by upregulating miR-1938 to suppress ADAM12, with no systemic ...
Proline Analogues Expose a Metabolic Weak Spot in the Chagas Disease Parasite
Trypanosoma cruzi, the single-celled parasite behind Chagas disease, has long frustrated drug developers... One of the more striking aspects of ...
Molecular Hydrogen Emerges as a Versatile Adjuvant in Cancer Therapy
A new review in Frontiers in Chemical Biology maps how molecular hydrogen reprograms oncogenic signaling, epigenetics, mitochondrial stress, and antitumor ...
Ginger Compound Zerumbone Halts Growth of Aggressive Uterine Cancer Cells in Lab Study
A new in vitro study reports that zerumbone, a sesquiterpene from wild ginger, arrests SK-UT-1 uterine leiomyosarcoma cells in the ...
Thai Yoom Noon Rice Extracts Show Anti-Cancer and DNA-Protective Effects in Lab Tests
Laboratory tests show that extracts of Thailand's flavonoid-rich Yoom Noon rice kill colorectal cancer cells, block their migration, and protect ...
Cellular Program Behind Aging May Also Shape Embryos, CHARGE Syndrome Review Suggests
A new review proposes that misregulation of developmental senescence, a transient embryonic cell-arrest program, may contribute to the congenital defects ...
Plant-Derived Sesquiterpenoids Show Potent Dual Attack on Lung Cancer Cells
Chemists isolated 28 sesquiterpenoids from the medicinal herb Carpesium abrotanoides, including five new compounds, and found that one of them ...
Cobalt Compound Halts Colorectal Cancer Cells by Jamming CDK4/6 and BCL2
A mononuclear octahedral cobalt(III) Schiff base complex arrests HT-29 colorectal cancer cells at the G1/S and G2/M checkpoints and triggers ...
Tin-Based Ladder Clusters Show Potent Anticancer Activity Beyond Cisplatin
Chemists have synthesized five dimethyltin cinnamate complexes featuring a ladder-like Sn4O4 core, with the lead compound showing potent, selective anticancer ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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