Engineering Life: How Synthetic Biology Is Rewriting Medicine, Farms and Factories
A sweeping new review charts how synthetic genetic circuits, synthetic chromosomes and engineered metabolism are transforming cancer therapy, drug delivery, ...
Tag: CAR-T Cell Therapy
Engineered CAR-T Cells That Make Their Own IL-2 Show Stronger Staying Power Against Pancreatic Cancer
A preclinical study shows that CAR-T cells engineered to secrete an Fc-fused IL-2(C125S) variant persist longer, retain mitochondrial fitness, and ...
Dual-Target CAR-T Cells Outsmart Antigen Shedding in Ovarian Cancer
Researchers have engineered biparatopic CAR-T cells that target both full-length MUC1 and the truncated MUC1β stub exposed after MUC1α shedding, ...
Silencing NOTCH1 Makes Leukemia Cells Vulnerable to CD19 CAR-T Attack
New research shows that blocking the NOTCH1 signaling pathway prevents leukemia cells from degrading the CD19 antigen, making them far ...
Taming the Cytokine Storm: How Doctors Are Making CAR T-Cell Therapy Safer
A comprehensive new review maps how clinicians are taming cytokine release syndrome, the most dangerous side effect of CAR T-cell ...
Silent Receptor Boost: Non-Signaling CARs Supercharge T-Cells Against Head and Neck Cancer
Researchers in Düsseldorf report that co-expressing a non-signaling EGFR-binding CAR alongside EGFRvIII-specific CAR T-cells enhances killing of head and neck ...
Engineered Immune Cells Push Melanoma Therapy Into a New Era
A new review details how tumor-infiltrating lymphocyte, CAR-T, and TCR-engineered cell therapies are transforming melanoma treatment and the engineering breakthroughs ...
Quantum Kernels Sharpen Prediction of CAR T-Cell Killing Power
Researchers used a 61-qubit quantum processor and projected quantum kernels to improve prediction of CAR T-cell cytotoxicity, with the largest ...
Rewiring the Engine: How Metabolism Could Unlock CAR-T Cells for Solid Tumors
A new review argues that engineering the metabolism of CAR-T cells, alongside neutralizing the hostile chemistry of tumors, is the ...
Digital Care Model Puts 306 Cell Therapy Patients to the Test in Landmark German Trial
A German randomized controlled trial has enrolled 306 patients to test whether a digitally supported, cross-sectoral care model can reduce ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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