Massive Single-Cell Atlas Maps Five Cancer Archetypes in Multiple Myeloma
A single-cell atlas of 341 multiple myeloma patients identifies five malignant transcriptional archetypes and an orthogonal proliferative program, enabling improved ...
Tag: CAR-T Cell Therapy
Lipid Metabolism Emerges as a Central Driver of Drug Resistance in Aggressive Lymphoma
A new review argues that lipid metabolic reprogramming acts as a convergence node for treatment resistance in aggressive non-Hodgkin lymphoma, ...
FDA Clears Trial of Dual-Target CAR T-Cell Therapy for Colorectal Cancer
The FDA has cleared a CU Anschutz clinical trial testing dual-target CAR T-cell therapy against advanced colorectal cancer and pediatric ...
Scientists Decode Design Rules for Building More Potent Chimaeric Antigen Receptors
A new Nature Biomedical Engineering study maps the sequence and structural features that determine whether chimaeric antigen receptors signal effectively, ...
New CAR T therapy targets fusion-driven solid tumors via GPNMB
Chimeric antigen receptor T cell therapy has transformed the treatment of certain blood cancers, delivering remissions in patients with leukemia ...
1,5-Pentanediamine from CRKP-colonized patients weakens CD19 CAR-T cells in vitro
A bacterial metabolite that circulates in the blood of patients colonized with carbapenem-resistant Klebsiella pneumoniae appears to sabotage one of ...
Iron-driven ferroptosis weakens CAR-T cell function and antitumor effectiveness
Chimeric antigen receptor T-cell therapy has transformed the treatment of several blood cancers, yet its success often depends on how ...
Cancer Treatment Saves Lives Without Dangerous Side Effects
CAR T-cell therapy has changed the outlook for people with some of the most aggressive blood cancers, turning a patient’s ...
New strategy strengthens CAR-T cells against solid tumors, potentially transforming cancer treatment
For years, CAR-T cell therapy has stood as one of cancer medicine’s most striking successes. By removing a patient’s T ...
Engineered CAR-T Cells Overcome Key Barriers in Solid Tumors
A new review published in Oncoscience argues that the next generation of CAR-T therapy for solid tumors will depend less ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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