How Shapeshifting Tumor Cells Outsmart Cancer Treatment
A new review explains how tumor cells reversibly switch identities through epigenetic and microenvironmental programs, driving metastasis and therapy resistance.
Tag: cancer stem cells
Enzyme USP45 Drives Liver Cancer Growth by Stabilizing Oncoprotein CIAP2
Researchers in China have shown that the deubiquitinating enzyme USP45 promotes hepatocellular carcinoma progression by removing K48-linked ubiquitin chains from ...
TGF-β2 Rewires Colon Cancer Cells to Survive Doxorubicin Through Autophagy and HMGB1
New research shows that the TGF-β2 signaling molecule steers metastatic colon cancer cells toward autophagy-mediated resistance to the chemotherapy drug ...
Gold Nanorods and Laser Light Strike at Cancer Stem Cells in Cats With Breast Tumors
A clinical trial in ten cats with spontaneous mammary carcinoma shows that gold nanorod-mediated plasmonic photothermal therapy significantly reduced circulating ...
Chemical Tags on RNA Drive Cancer Spread and Treatment Failure, Review Finds
A comprehensive review in Molecular Cancer details how chemical modifications to RNA molecules regulate tumor metastasis and therapy resistance, opening ...
Lab-Grown Tumor Organoids Illuminate How Cancers Evade, Tolerate, and Resist Treatment
A new review in Molecular Cancer positions patient-derived organoids as living systems for mapping how cancers tolerate, persist through, and ...
Immune Cells Hand Esophageal Cancer Its Stem-Like Edge Through an HNF1A/CXCL1 Circuit
New research shows that myeloid-derived suppressor cells drive stem-like properties in esophageal squamous cell carcinoma through an IL-1 beta-regulated HNF1A/CXCL1 ...
Pancreatic Cancer’s Moving Target: New Framework Calls for Continuously Evolving Treatment
A new review proposes a Dynamic Precision Oncology framework that monitors pancreatic cancer's evolving resistance mechanisms through longitudinal genomic, liquid ...
RUNX3 Emerges as a Master Switch Behind Cancer Chemoresistance
A new review in Cancer Cell International details how the tumor suppressor RUNX3 regulates apoptosis, drug efflux, cell cycle control, ...
Twenty-Five Years of Cancer Research: Stunning Breakthroughs and Sobering Setbacks
Marking the 25th anniversary of Nature Reviews Cancer, six leading researchers assess the transformative advances and unfulfilled expectations of a ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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