FBXO28 ubiquitinates BRD4 to fuel lung cancer cell malignancy
A study in non-small cell lung cancer models found that FBXO28 promotes proliferation, migration and invasion by ubiquitinating BRD4 and ...
Tag: cancer progression
Fibroblast collagen signal drives gut scarring and cancer in inflammatory bowel disease
A single-nuclei study reveals how CXCL14+ fibroblasts and SPP1+ macrophages form a collagen IV-driven feedback loop that promotes fibrosis and ...
Scaffold Protein LAMB1 Drives Esophageal Cancer Growth Through JAK2/STAT3 Pathway
New research shows that the extracellular matrix protein LAMB1 accelerates esophageal squamous cell carcinoma by activating JAK2/STAT3 signaling, suggesting it ...
Early NOTCH1 Mutation Shields Esophageal Tissue from Turning Cancerous
A new evolutionary analysis shows that NOTCH1 mutations flourish in normal esophageal tissue but epistatically suppress the later driver mutations, ...
One Cancer Gene, Two Fates: Study Shows Senescent Cells Split Into Tumor Blockers and Tumor Seeds
An NYU Abu Dhabi study in EMBO Reports shows that a single cancer-causing gene drives liver cells into distinct senescent ...
Betel Nut Chemical Shields Oral Cancer Cells From Copper-Driven Cell Death
New research shows that arecoline, the main alkaloid in betel nut, activates a ROS-NRF2-MT2A signaling axis that protects oral squamous ...
RNA-Binding RBM Proteins Emerge as Double-Edged Players in Cancer
A new review in Medical Oncology details how the RBM family of RNA-binding proteins acts as both tumor suppressors and ...
Mitochondrial DNA Copy Number Emerges as a Key Player in Cancer Progression
New research in The FEBS Journal links mitochondrial DNA copy number in cancer cells to mutational load, tumor growth gene ...
Root Canal Bacteria and Breast Cancer: New Meta-Analysis Finds No Clear Link, But Clues to Tumor Progression
A new systematic review and meta-analysis of 20 human studies finds no consistent association between root canal bacteria and breast ...
OLR1 Emerges as Key Driver of Gastric Cancer Growth and Immune Evasion
A new study shows that the lipid receptor OLR1 drives gastric cancer progression by activating NF-κB signaling and polarizing macrophages ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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