Aging Immune Cells May Undermine a Promising Cancer Therapy, Review Warns
A new review argues that immune aging and manufacturing stress, not just tumor biology, explain why gamma-delta T cell cancer ...
Tag: cancer immunotherapy
Turning Cold Tumors Hot: Dual-Target Therapy Offers New Hope for Platinum-Resistant Ovarian Cancer
A new review outlines how combining PARP inhibitors with immune checkpoint inhibitors can convert immunologically cold ovarian tumors into hot ...
Ancient Virus Hidden in Human DNA Engineered Into a Broad Cancer Vaccine Target
Scientists have engineered the envelope protein of human endogenous retrovirus-K to break immune tolerance and drive anti-tumor responses across multiple ...
VISTA: The Myeloid Checkpoint Rewriting the Rules of Cancer Immunotherapy
A new review argues that the immune checkpoint VISTA acts as a myeloid-centered axis in tumors, offering a route past ...
Machine Learning Model Predicts Which Lung Cancer Patients Will Respond to Immunotherapy
Researchers developed a random forest model integrating six clinical, inflammatory and molecular predictors that forecasts immunotherapy response in advanced lung ...
Morning infusions may boost immunotherapy survival benefit, major analysis finds
A new meta-analysis of nearly 12,000 patients links early-day immune checkpoint inhibitor infusions with markedly better survival in advanced solid ...
From CAR-T Cells to Cancer Organoids: The Technologies Set to Transform Clinical Oncology
An editorial from Clinical Cancer Bulletin maps the converging technologies — TCR-T cells, cancer organoids, multi-specific antibody-drug conjugates, nanotechnology, and ...
How Aging Cells Secretly Help Tumors Grow—and How Scientists Hope to Stop Them
A new review in Cancer Reports details how the senescence-associated secretory phenotype can both suppress and fuel tumors, and how ...
Computational Protein Design Supercharges Engineered Immune Cells Against Cancer and Viruses
Researchers at Bar-Ilan University and the Weizmann Institute used computational protein design to create an enhanced T-cell receptor, called SET, ...
Sugar Signature Reveals Which Tumor-Fighting T Cells Are Most Vulnerable
Researchers at Peking University have developed a single-cell method showing that low α2,6-linked sialylation marks the most potent tumor-reactive CD8+ ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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