A new review details how metabolically reprogrammed cancer-associated fibroblasts build immune-excluded and immunosuppressive tumor niches that undermine checkpoint blockade, and ...
Sustained blood CXCL1 elevation tracked attenuated Salmonella colonization in four preclinical tumor models.
Researchers identified PLPP4 as a functional marker of an ECM-enriched cancer-associated fibroblast subset that promotes tumor growth and metastasis via ...
A new study identifies the CXCL1/8-CXCR1/2 chemokine axis as a driver of the inflammatory tumor microenvironment and matrix remodeling in ...
A new review synthesizes evidence that DNA methylation, chromatin and non-coding RNA changes reshape immune and stromal cells in the ...
A new review finds that while cancer-associated fibroblasts clearly promote tumor growth and suppress natural killer cell activity in endometrial ...
In preclinical castration-resistant prostate cancer models, combining B7-H3 blockade with the MEK inhibitor trametinib overcame compensatory immune suppression and structural ...
A planned Dutch multicenter trial will test whether F-FAPI PET-CT can locate primary tumors in 50 adults with cancer of ...
KIT-led researchers show that inactivating the CD44 molecule reprograms tumor-promoting fibroblasts in pancreatic cancer, reducing fibrosis and immunosuppression and shrinking ...
A multi-omics study combining genomics and spatial transcriptomics finds that BRCA-mutated high-grade serous ovarian cancers show stronger interferon and inflammatory ...
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