Rare Liver Vascular Tumour Reported for the First Time in a Transplant Graft
A Dublin case report describes the first known hepatic small vessel neoplasm in a liver transplant recipient, detailing how this ...
Tag: c-Myc
Virtual screening yields two drug candidates that disable c-Myc in colorectal cancer
A multi-stage virtual screening campaign against the c-Myc/Max dimerization interface has identified two small molecules that suppress c-Myc protein, block ...
NDUFS1 links mitochondrial respiration to aggressive breast cancer behavior
A preclinical study links elevated NDUFS1, a mitochondrial complex I subunit, to breast cancer progression through increased respiration and PROX1–c-Myc ...
Faulty Connexin 43 Gene Reveals Hidden Signaling Switch Behind Rare Bone Disorder
A new study shows that GJA1 mutations in oculodentodigital dysplasia suppress Wnt/c-MYC signaling, driving a paradoxical inflammatory imbalance and excessive ...
Chaperonin Protein CCT2 Emerges as Key Driver of Aggressive Head and Neck Cancer and Cisplatin Resistance
New research shows that the chaperonin subunit CCT2 stabilizes the oncoprotein c-Myc to drive head and neck squamous cell carcinoma ...
Radiation Turns Childhood Brain Tumor Cells Senescent—and Senolytic Drugs Can Kill Them
New research shows that gamma irradiation drives p53 wild-type medulloblastoma cells into a senescent state that senolytic drugs such as ...
Light-Activated Molecular Degraders Put Protein Destruction Under Remote Control
Chemists have developed ruthenium-based photocaged PROTACs, called RuPHOTACs, that can be switched on with low-energy red light to selectively degrade ...
Serotonin Receptor Found to Drive Bone Cancer Spread and Chemotherapy Failure
Researchers report that the serotonin receptor HTR1D drives osteosarcoma metastasis and doxorubicin resistance through a c-MYC/MAPK feedback loop and CCL2/5-HT-mediated ...
Plant Arginine Mimic Canavanine Disrupts Cancer Cell Metabolism and Signals
New research shows that the plant-derived arginine analogue canavanine represses ASS1 in a c-Myc-independent manner and synergizes with arginine deprivation ...
Scientists Discover How a Common Vitamin Could Repair the Gut Barrier in Colitis
A new study identifies the PANK3 metabolic enzyme, suppressed by inflammation-driven c-Myc, as a key regulator of intestinal barrier failure ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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