Loss of Tet2 Rewires the Aging Bone Marrow to Drive Blood Cancers, Mouse Study Shows
A new conditional knockout mouse model shows that loss of the epigenetic regulator Tet2, combined with aging and a reshaped ...
Tag: bone marrow microenvironment
Hidden Scars in the Bone Marrow: Clonal Hematopoiesis Rewrites the Niche Before Cancer Strikes
Single-cell and spatial analyses of human bone marrow reveal that clonal hematopoiesis of indeterminate potential is marked by fibroblast expansion, ...
Single-Cell Map Reveals Five Macrophage States Behind Chemotherapy Resistance in AML
Single-cell RNA sequencing of post-chemotherapy AML bone marrow has identified five macrophage polarization states whose abundance tracks with treatment response ...
Inflammatory fingerprints reveal how multiple myeloma turns aggressive
A new study maps distinct inflammatory cytokine and PACAP-38 signatures in multiple myeloma, linking elevated IL-10 and other markers to ...
Altered bone marrow niche creates innate immune memory linked to heart dysfunction
A new study has identified the bone marrow as a possible command center for a form of immune memory that ...
ULK3 Supports Autophagy and Survival of Multiple Myeloma Cells
Multiple myeloma has long challenged researchers because the disease is not driven only by uncontrolled growth. Its malignant plasma cells ...
Proteomic Insights Link Myeloma Prognosis to Coagulation
In an innovative study published in Clinical Proteomics, researchers have made significant strides in understanding the complex landscape of multiple ...
HSC Numbers Depend on More Than Niches
Understanding the systemic regulation of haematopoietic stem cell (HSC) populations in the mammalian body has long fascinated scientists, particularly in ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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