PARP Inhibitor Plus Temozolomide Shows Promise in Relapsed Small-Cell Lung Cancer Trial
A phase Ib/II trial in China found that the oral PARP inhibitor HTMC0435 combined with temozolomide produced a manageable safety ...
Tag: Biomarkers
Machine Learning Uncovers Shared Immune Signatures Linking Sepsis and Aortic Aneurysm
An integrated bioinformatics and machine learning study identifies five shared diagnostic genes connecting sepsis and thoracic aortic aneurysm through immune ...
Umbilical Cord Test Reveals Hidden Prenatal Tobacco Exposure Missed by Mothers’ Own Reports
A multi-site study found umbilical cord cotinine in nearly all newborns whose mothers reported prenatal tobacco use and in about ...
Machine Learning Reads Speech to Detect Cognitive Impairment in Schizophrenia
A machine learning analysis of Korean speech shows that reduced lexical richness, syntactic complexity, semantic coherence, and sentiment polarity distinguish ...
Hidden RNA switches reshape cancer proteins and sabotage drug targets
A comprehensive multi-omics study catalogues thousands of cancer-specific isoform switches in melanoma, ovarian cancer, and AML, showing that most disrupt ...
Experimental Drug Tolinapant Boosts Immunotherapy Response in Advanced Solid Tumors
A phase I trial found that the IAP antagonist tolinapant combined with pembrolizumab was well tolerated and produced a 33 ...
Behavioral Complexity May Reveal Hidden Signs of Aging and Frailty
A new commentary in the journal Aging proposes that measuring behavioral complexity, including movement and physiological rhythms, could provide early ...
Can Doctors Predict Which Children With Crohn’s Disease Will Respond to Food-Based Therapy?
A new narrative review synthesizes the evidence on clinical, inflammatory, microbiome and multiomic predictors of response to exclusive enteral nutrition, ...
Synapse-Scanning PET Tracer Emerges as a Window Into Parkinson’s Disease Brain
A systematic review of seventeen studies finds that PET imaging of the synaptic vesicle glycoprotein 2A protein can reveal distinct ...
Cameras Catch Massage Loosening Stiff Tissue on the More Painful Side of the Body
Researchers used 3D digital image correlation of speckled skin to objectively measure how soft tissue manipulation improves tissue mobility, finding ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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