DNA Repair Gene Mutations Predict Dramatically Better Immunotherapy Outcomes in Colorectal Cancer
A study of 450 colorectal cancer patients shows that POLE and POLD1 proofreading gene mutations predict markedly better immunotherapy response ...
Tag: biomarker
Immune Cell Resident Gene RBPJ Emerges as Key to Lung Cancer Immunotherapy Success
A new single-cell study identifies the transcription factor RBPJ and CD103-positive tissue-resident memory T cells as central drivers of successful ...
Tiny Blood Vesicles Carrying TRAIL Predict Liver Spread of Pancreatic Cancer
Researchers at Sun Yat-sen University developed a nanoscale flow cytometry workflow that counts TRAIL-carrying extracellular vesicles in blood plasma, achieving ...
Four Metabolic Genes Predict Survival in Aggressive Liver Cancer
Researchers have built and validated a four-gene metabolic signature that predicts survival in intrahepatic cholangiocarcinoma more accurately than standard clinical ...
New Spatial Index Measures the Immune Barrier That Shields Tumours From Attack
Researchers have introduced the Spatial Immune Barrier Index, a spatial transcriptomics measure that quantifies the suppressive barrier holding immune cells ...
AI Turns Blood Proteins Into a Senescence Score That Predicts Death and Disease
Researchers used a deep learning model to compress 38 senescence-linked blood proteins into a single SASP Score that predicts mortality, ...
Simple Blood Ratio Predicts Survival in Young Bone Cancer Patients
A Vietnamese study of 100 young osteosarcoma patients found that a low lymphocyte-to-monocyte ratio measured after chemotherapy independently predicted poorer ...
AI Knockout Screen Reveals GSTP1 as a Driver of Lung Cancer Immunotherapy Resistance
A transformer-based in-silico gene knockout screen across 109 cell types has identified GSTP1 as a key driver of immunotherapy resistance ...
Cholesterol-Inflammation Combo Index Flags Heart Risk Before Disease Strikes
A new prospective cohort study of over 4,600 Chinese adults finds that a combined index of remnant cholesterol and inflammation ...
Frataxin Gene Emerges as Biomarker and Protective Switch in Glaucoma
A new study identifies the frataxin gene FXN as a diagnostic biomarker for primary open-angle glaucoma and shows that the ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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