Peptide-Binding Motifs Define Functional Architecture of Human Leukocyte Antigens
Researchers mapped the functional architecture of human leukocyte antigens across 155 class I and 93 class II allotypes into 40 ...
Tag: antigen presentation
Review Outlines Post-Infarction Cardiac Antigen Presentation and T-Cell Clonal Immunity Mechanisms
A narrative review examines MHC-restricted antigen presentation and clonal T-cell responses after myocardial infarction, highlighting evidence gaps in antigen specificity ...
Targeting JAK-STAT Signaling May Help Overcome Immunotherapy Resistance in Glioma
A narrative review examines how targeting JAK–STAT signaling, particularly STAT3, could remodel the suppressive glioma microenvironment and counter immune checkpoint ...
Histotripsy Triggers Distinct Anti-Tumor Immune Responses Compared With Radiotherapy in Mice
In a murine model of pancreatic adenocarcinoma, ultrasound histotripsy and radiotherapy induced local tumor control while activating distinct myeloid and ...
Single-Cell Atlas Uncovers Immune Activation and Cellular Diversity Across Endometriosis Subtypes
A single-cell RNA sequencing analysis reveals subtype-specific immune microenvironment heterogeneity, altered epithelial crosstalk, and fibrosis-linked fibroblast infiltration across distinct endometriosis ...
Bacterial Vesicles Show Promise as Self-Adjuvanted Vaccine Platforms
A 2025 review in Discover Immunity explores how bacterial extracellular vesicles can serve as self-adjuvanted vaccine platforms, highlighting their immunomodulatory ...
Macrophage PD-L1 Loss Reduces CD80 Surface Expression
A new study in Frontiers in Oncology reveals that PD-L1 deletion or blockade in macrophages consistently reduces surface levels of ...
Strategies Examined to Restore Antitumor Immunity in Immunologically Cold Tumors
A scientific review examines how cellular, vascular, and metabolic barriers disrupt immune coordination in solid tumors and outlines multi-targeted strategies ...
Cryoablation Advances Anti-Tumor Immunity and Combination Strategies Against Solid Cancers
A review highlights how cryoablation eradicates local solid tumors and primes T cells by naturally releasing antigens, offering new opportunities ...
Pathogens may help tumors dodge immunotherapy by remodeling the immune system
A new review proposes that persistent pathogens remodel the tumor immune microenvironment, promoting immune escape and immunotherapy resistance through checkpoints, ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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