Exercise-linked muscle peptide reduces fatty liver through ACE2 in mice
A study in diabetic mice with fatty liver found that exercise-linked muscle peptide MOTS-c reduced steatosis through an AMPK–ACE2 pathway.
Tag: AMPK
TIMD4-targeted nanoparticles reduce colitis inflammation in mice
A macrophage-targeted TIMD4 peptide nanoparticle reduced inflammation and monocyte recruitment in a mouse colitis model without establishing clinical benefit in ...
Mouse study links spinal Hsp90 inhibition to enhanced morphine pain relief through DUSP15 in CGRP neurons
In mice, spinal Hsp90 inhibition enhanced morphine pain relief, and DUSP15 knockdown in CGRP neurons reversed that effect.
Post-remission muscle loss in rheumatoid arthritis improved by dipyridamole in mice
In a mouse model of rheumatoid arthritis, dipyridamole improved persistent muscle loss and dysfunction after joint inflammation subsided, alongside restored ...
NUAK1 and NUAK2 drive colorectal cancer metabolic changes in cells
Human tissue associations and cell experiments link NUAK1 and NUAK2 to colorectal cancer growth, migration and metabolic reprogramming through AMPK ...
SWAP70 promotes liver cancer growth through CPT1A-dependent fatty acid oxidation
Cell, tissue and mouse experiments link elevated SWAP70 to advanced human liver tumors and show that it supports hepatocellular carcinoma ...
Cellular Recycling System Emerges as Master Switch for Healing Chronic Wounds
A new review details how the cellular recycling pathway autophagy coordinates every stage of skin wound healing and how drugs, ...
Mitochondrial Sirt3 loss disrupts fat-burning brake in female fat cells
New research shows that losing the mitochondrial enzyme Sirtuin 3 selectively impairs AMPK–Acc1 antilipogenic signaling in female fat cells, driving ...
A rogue microRNA sabotages the neuron’s mitochondrial cleanup crew in Alzheimer’s disease
Deep inside the neurons of an aging brain, mitochondria are quietly failing. These organelles, which supply the enormous energy demands ...
How a Cellular Fuel Sensor Helps Red Blood Cells Survive Anemia
A new study reveals how the energy sensor AMPK stabilizes the oxygen-responsive protein HIF-2α to drive red blood cell maturation ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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