Astrocyte Fibronectin Emerges as Key Driver of Blood–Brain Barrier Failure in Alzheimer’s Disease
A new Nature Aging study identifies astrocyte-derived fibronectin as the molecular link between the APOE ε4 allele, amyloid pathology, and ...
Tag: Alzheimer’s disease
Alzheimer’s disease quietly rewires the bone marrow, study finds
New research in Nature Neuroscience shows that Alzheimer's disease disrupts myeloid cell production in the bone marrow via type I ...
Lonely Sleep Waves: How Tau Tangles Quietly Sabotage the Aging Brain’s Memory.
New research shows that frontal tau pathology fragments the traveling slow waves of deep sleep, weakening overnight memory consolidation and ...
APOE and neuromelanin shape Alzheimer’s risk in human brain’s stress hub
Deep in the brainstem, a tiny, pigment-darkened cluster of neurons called the locus coeruleus acts as the brain's principal source ...
Gut Microbes Emerge as Central Players in Diabetes, Heart and Brain Disease
A comprehensive review finds that gut microbial imbalance drives metabolic, neurodegenerative, cardiovascular and gastrointestinal diseases through defined metabolite signaling pathways.
Unique amyloid-β filament structure found in APP Flemish mutation carriers
Cryo-electron microscopy has revealed an entirely new amyloid-β filament fold in the brains of individuals carrying one of the rarest ...
Notoginseng polysaccharide nanoparticles reprogram microglia metabolism to ease Alzheimer’s disease
Alzheimer's disease research has spent decades fixated on amyloid plaques and tau tangles, but a team of scientists in China ...
How Aging and Alzheimer’s Reshape Human Microglia and Brain Perivascular Macrophages
Alzheimer’s disease has long been described through the lens of neurons: the loss of synapses, the accumulation of amyloid-β plaques, ...
How Autophagy Maintains Brain Health and Contributes to Disease
The brain depends on an intricate internal recycling system to keep its exceptionally long-lived cells functioning. A new review in ...
Tau protein linked to Alzheimer’s disrupts nerve cells’ energy-producing mitochondria
A newly identified mechanism may explain how tau protein helps drive Alzheimer’s disease and other tauopathies, according to research from ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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