Computer model finds timing and dose govern simulated endothelial repair
A multiscale simulation found that endothelial repair depended on early, moderate AKT activation and on balancing local nitric oxide production ...
Tag: AKT signaling
EP300 Degradation and AKT Inhibition Slow Osteosarcoma in Preclinical Models
A PROTAC that degrades EP300 combined with AKT inhibition slowed tumor growth and extended survival in patient-derived osteosarcoma mouse models, ...
Mitochondrial Protein Miro1 Emerges as a Driver of Muscle Insulin Resistance in Type 2 Diabetes
Researchers report that the mitochondrial protein Miro1 accumulates in the skeletal muscle of patients with type 2 diabetes, driven by ...
Ovarian Cancer Cells Outsmart CXCR4 Blockade at High Doses, Study Finds
New research shows that blocking the CXCL12/CXCR4 signaling axis in ovarian cancer cells produces a paradoxical biphasic response, with moderate ...
DNMT1 Regulates Testosterone Synthesis in Aged Rat Leydig Cells via FTO‐Mediated HSP90AA1 m6A Levels
Aging Cell study reveals how declining DNMT1 triggers FTO-mediated m6A changes that silence HSP90AA1 and AKT signaling, driving testosterone loss ...
Lactate Marks on Histones Drive Wilms Tumor Growth Through a Self-Reinforcing Genetic Loop
New research reveals that lactate-driven histone H3K18 lactylation activates a PSRC1/AKT/HIF-1α positive feedback loop that propels the malignant progression of ...
Blue Bacterial Pigment Boosted 2.3-Fold Shows Diabetes and Obesity Potential
Scientists have boosted bacterial production of the blue pigment indigoidine more than twofold and shown it inhibits digestive enzymes linked ...
Milk Protein Gene CSN3 Emerges as a Driver of Colorectal Cancer Growth Through AKT Signaling
New research shows that the milk protein gene CSN3 is elevated in colorectal cancer and drives tumor growth, invasion, and ...
Toad Venom Compound Bufalin Blocks Melanoma Growth by Switching Off AKT Signaling
New research shows that bufalin, a steroid from traditional Chinese toad venom, suppresses melanoma growth, metastasis and angiogenesis by reducing ...
Scientists Discover PTCHD4 as a Novel Driver of Cellular Aging and Age-Related Disease
Researchers have identified the little-studied transmembrane protein PTCHD4 as a novel regulator of cellular senescence whose deletion extends lifespan and ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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