Collagen Scaffold in Tumors Primes Colorectal Cancer Cells to Evade Chemotherapy
Patient-derived organoid and xenograft models reveal that a collagen I-rich tumor matrix activates TGFβ signaling and LTBP2 expression, priming colorectal ...
Tag: 5-fluorouracil
Tiny Stem Cell Vesicles Loaded with miR-124 Strike Dual Targets to Curb Colorectal Cancer
Scientists engineered stem cell-derived vesicles to deliver tumor-suppressive miR-124 into colorectal cancer cells, silencing EZH2, weakening STAT3 signaling, and shrinking ...
Gallic Acid Shrinks Tumors in Mice While Sparing Blood Cells, Study Finds
A new preclinical study shows that orally delivered gallic acid significantly inhibited sarcoma tumor growth in mice by suppressing proliferation, ...
Sugar-Coated Carbon Nanotubes Unleash Chemotherapy on Demand in Tumor-Like Acidity
Researchers have engineered glucuronic acid and polyethyleneimine-functionalized carbon nanotubes that load 5-fluorouracil with 88 percent efficiency and release it preferentially ...
Gut Bacterial Brew Supercharges Chemotherapy Against Colorectal Cancer Cells in Lab Study
A cell-free supernatant from the probiotic bacterium Limosilactobacillus reuteri significantly enhanced 5-fluorouracil-induced apoptosis in colorectal cancer cells in vitro, suggesting ...
Iron Outperforms Magnesium in Carbon Frameworks That Capture Chemotherapy Drug Residues
A new density functional theory study shows that iron-centered nitrogen-doped carbon coordination frameworks bind the chemotherapy drug 5-fluorouracil far more ...
Different Chemotherapy Drugs Leave Different Fingerprints on the Brain’s Networks
A resting-state fMRI study of 97 cancer patients finds that fluorouracil-based and carboplatin-based chemotherapy regimens are associated with distinct alterations ...
New 5-FU Derivative EB-18 Shows Potency Against Resistant Cancers
Researchers have engineered EB-18, a phosphonium-substituted derivative of the classic chemotherapy drug 5-fluorouracil that outperforms 5-FU and standard agents in ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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