Neuroscape and Samsung Collaborate to Study Cognitive Changes Over Time

An ambitious new longitudinal study led by UCSF’s Neuroscape research center in collaboration with Samsung aims to revolutionize our understanding of cognitive aging through cutting-edge wearable technology. The Neuroscape Technology for Aging Health – Digital Approaches (TAH-DA) study seeks to detect early biometric predictors of cognitive decline by monitoring a broad spectrum of physiological signals in real time over a full year.

Participants, spanning adults aged 40 to 89 and stratified by decade, are equipped with Samsung’s Galaxy Watch and Galaxy Tab A9 to facilitate continuous health tracking and cognitive engagement from the comfort of their own homes. The Galaxy Watch collects a comprehensive array of biometrics, including electrocardiogram (ECG), heart rate, blood pressure, blood oxygen saturation, and bioelectrical impedance analysis (BIA) for body composition. Additionally, the device quantifies sleep quality and patterns through skin temperature and activity monitoring—daily step counts and sleep cycles among them—generating a rich data stream for in-depth analysis.

This innovative amalgamation of wearable sensor data paired with Neuroscape’s digital cognitive interventions creates a virtual laboratory unparalleled in scope. The Galaxy Tab serves as the platform for digital cognitive evaluations and interactive games specifically designed to challenge and enhance neurocognitive control functions, which typically deteriorate with age. Participants complete these assessments at baseline, post-intervention, and after nine months to gauge both immediate and lasting effects on brain function.

Unlike conventional laboratory studies constrained by rigid experimental conditions, TAH-DA collects real-world biometric and behavioral data continuously, offering unprecedented ecological validity. Harnessing this passive continuous monitoring approach, the research team aims to identify digital biomarkers—physiological and behavioral signatures predictive of cognitive change—long before clinical symptoms manifest.

The study utilizes Neuroscape’s Nexus platform for seamless remote trial management, ranging from recruitment and consent to deployment of cognitive tasks and collection of self-reported surveys. To streamline participant experience, AI-powered tools such as chatbots and virtual assistants ensure support throughout the enrollment and trial phases.

By integrating multidisciplinary expertise across neuroscience, digital health, and wearable technology, this collaborative effort stands at the forefront of neurotechnology innovation. The resulting insights and sophisticated predictive algorithms hold promise for transformative applications in personalized brain health monitoring and early intervention strategies.

This landmark project exemplifies how consumer electronics increasingly intersect with neuroscience to unlock new frontiers in preventive medicine and digital therapeutics. As Praveen Raja, Vice President of Digital Health at Samsung Research America, articulates, the endeavor pushes the digital health ecosystem forward by deploying biometric data to better understand and ultimately mitigate cognitive decline.

With thousands of hours of multivariate data anticipated, TAH-DA heralds a future where everyday devices not only capture lifestyle metrics but actively promote cognitive resilience across the lifespan.

Keywords

Neuroscience, Cognitive Aging, Digital Biomarkers, Wearable Technology, EEG, ECG, Digital Health, Remote Clinical Trials, Cognitive Interventions, Brain Health