Microglial deletion induces despair-like behavior associated with astrogliosis

Subject of Research: Psychology & Psychiatry

Article Title: Microglial deletion induces despair-like behavior associated with astrogliosis

Article References: Wang, X., Liao, S.-H., Wang, N., Chen, Y.-T., Huang, R.-H., Li, D.-J., Jiang, W.-Y., Li, X.-W., Gao, T.-M., & Yang, J.-M. (2026). Microglial deletion induces despair-like behavior associated with astrogliosis. Translational Psychiatry. https://doi.org/10.1038/s41398-026-04325-7

Image Credits: AI Generated

DOI: 10.1038/s41398-026-04325-7

Keywords: astrocyte activation and astrogliosis, effects of microglia depletion on brain function, glial cell interactions in neuropsychiatry, implications for depression treatment targeting glial cells, microglia and behavioral despair, microglia role in neuroinflammation, microglia-astrocyte crosstalk, microglial deletion and depression-like behavior, neurobiological mechanisms of despair-like behaviors, neuroimmune interactions in psychiatric disorders, neuroinflammation in depression models