Wednesday, October 22, 2025
Science
No Result
View All Result
  • Login
  • HOME
  • SCIENCE NEWS
  • CONTACT US
  • HOME
  • SCIENCE NEWS
  • CONTACT US
No Result
View All Result
Scienmag
No Result
View All Result
Home Science News Cancer

Microbiota enterotoxigenic Bacteroides fragilis-secreted BFT-1 promotes breast cancer cell stemness and chemoresistance through its functional receptor NOD1

April 25, 2024
in Cancer
Reading Time: 2 mins read
0
Image
66
SHARES
596
VIEWS
Share on FacebookShare on Twitter
ADVERTISEMENT

Tumor-resident microbiota in breast cancer promotes both the initiation and progression of cancer. However, the potential of targeting microbiota to enhance the efficacy of breast cancer treatment has not been comprehensively explored. In this study, researchers analyzed the microbial composition within breast tumors and identified a notable enrichment of ETBF in patients who exhibited resistance to taxane-based neoadjuvant chemotherapy.

Image

Credit: Wei Ma, Lu Zhang, Weilong Chen, Zhaoxia Chang, Juchuanli Tu, Yuanyuan Qin, Yuwen Yao, Mengxue Dong, Jiajun Ding, Siqin Li, Fengkai Li, Qiaodan Deng, Yifei Yang, Tingting Feng, Fanrong Zhang, Xiying Shao, Xueyan He, Lixing Zhang, Guohong Hu, Quentin Liu, Yi-Zhou Jiang, Shu Zhu, Zhi Xiao, Dan Su, Tong Liu, Suling Liu

Tumor-resident microbiota in breast cancer promotes both the initiation and progression of cancer. However, the potential of targeting microbiota to enhance the efficacy of breast cancer treatment has not been comprehensively explored. In this study, researchers analyzed the microbial composition within breast tumors and identified a notable enrichment of ETBF in patients who exhibited resistance to taxane-based neoadjuvant chemotherapy.

Key findings from the study include:

  1. Even at low biomass levels, ETBF secretes a toxic protein, BFT-1, which enhances breast cancer cell stemness and chemoresistance.
  2. Mechanistic investigations revealed that BFT-1 directly binds to the NOD1, a protein highly expressed in the ALDH+ BCSCs. The interaction between BFT-1 and NOD1 leads to the stabilization of NOD1.
  3. NOD1 cooperated with G-associated kinase (GAK) to phosphorylate NUMB, leading to its lysosomal degradation. This process activated the NOTCH1-HEY1 signaling pathway, thereby increasing the number of BCSCs.
  4. Inhibition of NOD1 and clearance of ETBF significantly increase chemotherapy sensitivity by impairing breast cancer stem cells. 

These findings suggest that inhibiting the NOD1 pathway and eliminating ETBF from the tumor microenvironment could potentially sensitize breast cancer cells to chemotherapy by impairing BCSCs. These results highlight the importance of considering the microbiome as a factor in cancer treatment and represent a promising avenue for developing novel therapeutic strategies aimed at enhancing the efficacy of existing breast cancer treatments. The work entitled “Microbiota enterotoxigenic Bacteroides fragilis-secreted BFT-1 promotes breast cancer cell stemness and chemoresistance through its functional receptor NOD1” was published on Protein & Cell (published on Mar 4, 2024).

DOI: 10.1093/procel/pwae005



Journal

Protein & Cell

DOI

10.1093/procel/pwae005

Method of Research

Experimental study

Subject of Research

Animals

Article Title

Microbiota enterotoxigenic Bacteroides fragilis-secreted BFT-1 promotes breast cancer cell stemness and chemoresistance through its functional receptor NOD1

Article Publication Date

4-Mar-2024

Share26Tweet17
Previous Post

The Lundquist Institute receives $2.6 million grant from U.S. Army Medical Research Acquisition Activity to develop wearable biosensors

Next Post

Revolutionizing men’s sexual health: AI’s pivotal role in erectile dysfunction management

Related Posts

blank
Cancer

UCLA Researchers Create Universal Single-Product Immunotherapy for Breast Cancer

October 22, 2025
blank
Cancer

New Technique Enables Researchers to Monitor Chemotherapy Drugs Within Cells

October 22, 2025
blank
Cancer

Breakthrough Relief for Debilitating Menopause Symptoms in Breast Cancer Survivors

October 22, 2025
blank
Cancer

Innovative Smart Learning Technology Addresses Training Gaps in Cervical Cancer Prevention

October 22, 2025
blank
Cancer

$2.2M NIH Grant Advances Next-Generation Cancer Therapies at Corewell Health

October 22, 2025
blank
Cancer

New Two-Drug Combination Shows Promise in Enhancing Colorectal Cancer Treatment

October 22, 2025
Next Post
Revolutionizing men's sexual health: AI's pivotal role in erectile dysfunction management

Revolutionizing men's sexual health: AI's pivotal role in erectile dysfunction management

  • Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study

    Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study

    27570 shares
    Share 11025 Tweet 6891
  • University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept

    979 shares
    Share 392 Tweet 245
  • Bee body mass, pathogens and local climate influence heat tolerance

    648 shares
    Share 259 Tweet 162
  • Researchers record first-ever images and data of a shark experiencing a boat strike

    516 shares
    Share 206 Tweet 129
  • Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function

    484 shares
    Share 194 Tweet 121
Science

Embark on a thrilling journey of discovery with Scienmag.com—your ultimate source for cutting-edge breakthroughs. Immerse yourself in a world where curiosity knows no limits and tomorrow’s possibilities become today’s reality!

RECENT NEWS

  • Infertility’s Impact on Men’s Psychological and Sexual Health
  • Pathogenic Bacteria Outsmart Epithelial Cell Defense
  • UCLA Researchers Create Universal Single-Product Immunotherapy for Breast Cancer
  • Engineers Develop Emergency Management Simulation Game to Prepare for Derecho Events

Categories

  • Agriculture
  • Anthropology
  • Archaeology
  • Athmospheric
  • Biology
  • Blog
  • Bussines
  • Cancer
  • Chemistry
  • Climate
  • Earth Science
  • Marine
  • Mathematics
  • Medicine
  • Pediatry
  • Policy
  • Psychology & Psychiatry
  • Science Education
  • Social Science
  • Space
  • Technology and Engineering

Subscribe to Blog via Email

Enter your email address to subscribe to this blog and receive notifications of new posts by email.

Join 5,188 other subscribers

© 2025 Scienmag - Science Magazine

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
No Result
View All Result
  • HOME
  • SCIENCE NEWS
  • CONTACT US

© 2025 Scienmag - Science Magazine

Discover more from Science

Subscribe now to keep reading and get access to the full archive.

Continue reading