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Fenton-like Reaction: Breaking Down Sulfamethoxazole in Water

January 28, 2026
in Earth Science
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Recent advances in environmental chemistry have given rise to innovative methods aimed at eliminating pollutants from water sources. A significant study led by researchers Zhou, Li, and Pan delves into the degradation of sulfamethoxazole, a commonly used antibiotic, through a Fenton-like reaction activated by ultraviolet light and hydrogen peroxide. This research highlights both the efficacy of this method and the underlying mechanisms responsible for the successful breakdown of sulfamethoxazole, making it pertinent to contemporary environmental remediation efforts.

The study centers on a pressing issue: the presence of pharmaceutical contaminants in water bodies. Sulfamethoxazole and similar compounds often find their way into aquatic environments through various pathways—including wastewater discharge and agricultural runoff—where they pose risks to wildlife and potentially human health. The persistence of antibiotics in water can lead to the development of antibiotic-resistant bacteria, an emerging global health crisis.

To combat this environmental challenge, the researchers implemented a method utilizing a Fenton-like reaction, which traditionally relies on iron catalysis to generate hydroxyl radicals from hydrogen peroxide. This process is known for its effectiveness in degrading organic pollutants. Zhou and his team innovatively adapted this concept by incorporating ultraviolet light, a well-known catalyst in photochemistry, to enhance the reaction kinetics, resulting in a more potent degradation process.

The study method involved systematically testing various conditions, including sulfur concentration, UV light intensity, and hydrogen peroxide levels, to determine the optimal parameters for maximal degradation efficiency. By carefully analyzing the reaction conditions, the researchers sought to establish a more effective and practical approach for wastewater treatment facilities, particularly those dealing with pharmaceutical contaminants.

A key finding from this research indicates that the combination of UV light and hydrogen peroxide significantly accelerates the degradation of sulfamethoxazole compared to systems that do not utilize UV light. This suggests that not only does the Fenton-like reaction work effectively in degrading this antibiotic, but the introduction of UV light catalyzes the production of reactive species, driving the reaction forward more rapidly.

Moreover, the study investigated the degradation byproducts formed during the reaction process. Understanding these intermediates is crucial, as they can sometimes be more toxic than the original compound. The researchers employed advanced analytical techniques to track the transformation of sulfamethoxazole through various stages, revealing a complex matrix of reactions that contribute to the overall efficacy of the method.

Throughout their experiments, the team meticulously documented the influence of different environmental conditions, such as pH and temperature, on the degradation process. These parameters play a critical role in the efficiency of the Fenton-like reaction, as they can significantly affect the production of hydroxyl radicals, which are essential for breaking down complex organic molecules.

In addition to demonstrating the effectiveness of their approach, the researchers also discussed the scalability of this technology for real-world applications. They emphasized the importance of translating laboratory successes into practical solutions for wastewater treatment facilities. Understanding how to optimize and scale up the Fenton-like reaction could pave the way for more sustainable practices in managing pharmaceutical pollution.

The implications of this research extend beyond the immediate findings. As the world grapples with increasing regulations on water quality and the need for sustainable environmental practices, innovations like the one proposed by Zhou and his colleagues offer promising avenues for remediation. The positive outcomes from their study could lead to more robust frameworks for tackling other emerging contaminants that threaten water safety.

Furthermore, the research community’s interest in advanced oxidation processes such as the one explored in this study has been growing. These methods are increasingly seen as vital tools in addressing not only pharmaceutical pollutants but other persistent organic pollutants that challenge water treatment systems worldwide. As such, the work of Zhou et al. contributes valuable insights into the broader discourse on water pollution and remediation strategies.

In conclusion, the study on the Fenton-like reaction augmented with UV light and hydrogen peroxide showcases an innovative and effective approach to degrade sulfamethoxazole in water. The findings emphasize the critical need for continual advancements in environmental remediation technologies to address the challenges posed by pharmaceutical contaminants. This research not only contributes to the understanding of chemical degradation processes but also serves as a hopeful step toward more sustainable water management practices.

As researchers continue to explore and expand upon these findings, the potential for applying such methods to other pollutants could further revolutionize our approach to environmental health and safety. The ongoing commitment to addressing water quality issues will undoubtedly remain a top priority as society seeks to balance development with ecological preservation.

This dynamic interplay between research and application speaks to the urgency and relevance of environmental science and its critical role in safeguarding public health against the backdrop of a rapidly changing world.


Subject of Research: Degradation of sulfamethoxazole using Fenton-like reaction based on UV/H₂O₂.

Article Title: Study on the effect and mechanism of Fenton-like reaction based on UV/H₂O₂ to degrade sulfamethoxazole in water.

Article References: Zhou, B., Li, G., Pan, Z. et al. Study on the effect and mechanism of Fenton-like reaction based on UV/H₂O₂ to degrade sulfamethoxazole in water. Environ Sci Pollut Res (2026). https://doi.org/10.1007/s11356-026-37390-y.

Image Credits: AI Generated

DOI: https://doi.org/10.1007/s11356-026-37390-y

Keywords: Fenton-like reaction, UV light, hydrogen peroxide, sulfamethoxazole degradation, environmental chemistry, wastewater treatment, pharmaceutical contaminants.

Tags: agricultural runoff and water pollutionantibiotic pollution and human healthcombating antibiotic-resistant bacteriadegradation of sulfamethoxazole in waterenvironmental remediation techniquesFenton-like reaction for water treatmenthydrogen peroxide as a catalysthydroxyl radicals generation in water treatmentinnovative methods in environmental chemistrypharmaceutical contaminants in aquatic environmentsultraviolet light in chemical reactionswastewater discharge impacts
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