Medicine
In vivo CRISPR base editing for treatment of Huntington’s disease
Shirguppe, S., Gapinske, M., Swami, D. et al. In vivo CRISPR base editing for treatment of Huntington’s disease. Nat. Biomed....
AI Tool Acts Like a Molecular Shrink Ray, Redesigns Proteins Reliably
Duke University School of Medicine researchers have unveiled Raygun, an artificial intelligence framework that can redesign proteins at a scale...
Rational Design of Disordered Proteins Enables Sequence-Function Investigation
Intrinsically disordered proteins (IDRs)—segments that do not adopt a single stable 3D structure—are common across life and perform crucial cellular...
Short ACE2 Isoform Increases in Adipose Tissue of Women With Obesity
A recent study adds a new piece to the emerging map of ACE2 biology—an essential entry point exploited by SARS‑CoV‑2...
Mitochondria plaques in Alzheimer’s linked to buildup and lysosomal dysfunction
New evidence links a failure of cellular cleanup to the distinctive brain damage of Alzheimer’s disease. In a study in...
Conformations of Neuronal Na+, K+-ATPase Isoforms and a Disease-Causing Variant
A new viral-science report spotlights how a pair of neuronal ion pumps—neuronal Na⁺,K⁺-ATPase isoforms—switch between distinct active shapes, and how...
Ocean Sounds During ROP Exams Improve Physiology, Pain, and Comfort in Preemies
Premature infants undergoing retinopathy of prematurity (ROP) screening can experience repeated stress responses during examinations—an issue that matters because even...
American College of Lifestyle Medicine urges remission as chronic disease goal
ST. LOUIS—The American College of Lifestyle Medicine (ACLM) has launched Project Remission, a new initiative urging healthcare systems to rethink...
Study tracks mosaic chromosome changes to reveal factors shaping blood cell clones
A new study published in Nature Communications reports a longitudinal map of mosaic chromosomal alterations, tracking how these genomic events...
Scoping Review Highlights Silent Struggles From Internalizing Disorders After HIE
Newborns who suffer hypoxic-ischemic encephalopathy (HIE)—a form of brain injury caused by oxygen deprivation around birth—may survive, but the aftermath...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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