Cancer
Dark DNA’s Long RNAs Emerge as Master Regulators of Colorectal Cancer
A major new review shows that long non-coding RNAs orchestrate the colorectal cancer tumour microenvironment, offering new biomarkers and therapeutic...
Neutrophils in Cancer: The Immune Cells That Turn Traitors and Healers
A comprehensive new review reveals how neutrophils, the immune system's most abundant white blood cells, are co-opted by tumors to...
Bile Acids Emerge as Master Regulators Linking Gut Microbes, Immunity and Cancer
A new commentary in Holistic Integrative Oncology argues that bile acids act as master signaling molecules linking liver metabolism, gut...
Tumor Vesicles Loaded with SPP1 Rewire Fibroblasts to Shield Lung Cancer from Immunity
New research shows that lung adenocarcinoma cells package the protein SPP1 into extracellular vesicles to reprogram fibroblasts into an MMP11-positive...
Blocking a Single Kinase May Steer Immune Cells Toward Safer Atherosclerotic Plaques
New research shows that removing protein kinase C delta reprograms macrophage metabolism to suppress inflammatory pyroptotic cell death and stabilize...
ATR Inhibitors Supercharge Bladder Cancer Chemotherapy in Patient-Derived Organoids
Dutch researchers have shown that combining the bladder chemotherapy drug mitomycin C with ATR kinase inhibitors eradicates patient-derived non-muscle invasive...
Beyond KRAS G12C: New Drug Wave Targets Once-Undruggable Cancer Driver
A new review maps the fast-moving landscape of next-generation KRAS inhibitors, degraders, and combination strategies now advancing beyond the first...
Glutamine Joins Gemcitabine and Nab-Paclitaxel in Advanced Pancreatic Cancer Trial
The phase 1 GlutaPanc trial shows that l-glutamine can be safely combined with first-line gemcitabine and nab-paclitaxel in advanced pancreatic...
Cancer Drug Lapatinib Offers Safer HER2 Route for Patients With Failing Hearts
A new clinical case report shows that the oral HER2 inhibitor lapatinib, with its short half-life and low cardiac toxicity,...
Thyroid Cancer Protein Rewires Tumor Metabolism and Drives Drug Resistance
New research shows the protein ECT2 drives papillary thyroid carcinoma growth by suppressing lipoic acid metabolism, activating PI3K/AKT signaling and...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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