Scientists discover the molecular switch that lets TNF trigger cell death
A new study identifies the E3 ubiquitin ligase HERC4 as the long-sought molecular switch that licenses RIPK1 to initiate TNF-induced ...
Satellites Reveal How Warming Reshapes Pakistan’s Growing Seasons From Coast to Karakoram
The first national-scale satellite assessment of vegetation phenology in Pakistan shows that minimum temperatures drive earlier springs in mountain ecosystems ...
Breast Cancer Cells Recruit Immune Allies Through TNFAIP3 to Drive Metastasis
A new study shows that high TNFAIP3 expression in breast cancer cells drives CCL2/CCR2-mediated M2-like macrophage polarization and that combining ...
Estrogen receptor fuels breast cancer growth through an RNA-tagging loop, study finds
New research reveals that estrogen receptor alpha drives an m6A-dependent RNA stabilization pathway through HNRNPC and DDX6 that promotes the ...
Low Pay, Burnout and Depression Drive Poor Welfare Among Ugandan Doctors
A new study of 111 doctors in Uganda's Central Region finds that 72 percent have poor mental well-being, with low ...
Two Classic Math Methods Nail the Masses of Bottom-Quark Mesons to Within Half a Percent
A new study combines the matrix Numerov and variational methods with a screened-potential-inspired model to reproduce B, Bs, and Bc ...
Single-cell atlas of human liver pinpoints scar macrophages as drug target for fibrosis
A 649,295-cell single-cell atlas of human livers has revealed a pro-inflammatory OLR1-positive scar-associated macrophage population that expands across chronic liver ...
Finer Birthweight Categories Reveal Hidden Mortality Risks in Preterm Infants
A large cohort study of more than 25,000 preterm US infants shows that subdividing traditional small- and appropriate-for-gestational-age birthweight categories ...
Scientists Find Active Pseudomonas Phages and Their Bacterial Host in Human Breast Milk
Researchers have isolated six infectious Pseudomonas aeruginosa bacteriophages, along with a live strain of the bacterium itself, directly from human ...
Brain-Penetrating Acridine Drug JP-1302 Cripples Cancer Cells by Shutting Down Ribosome Factory
A brain-penetrating acridine compound originally developed as an adrenergic receptor antagonist potently shuts down RNA polymerase I transcription, degrades the ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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