Crushing Pills in Nursing Homes: One in Three Manipulations May Be Unsafe
A national Italian study of 82 long-term care facilities found that nearly one in four solid oral medications is altered...
Floppy Lipids, Not Rigid Ones, Turn Out to Be the Secret to Ultra-Slow Drug Release
Harvard researchers report that unsaturated phospholipids spontaneously form multilamellar, multivesicular liposomes that dramatically boost loading and achieve weeks-long, ultra-slow release...
Natural Alkaloids Show Promise as Disruptors of Bacterial Quorum Sensing
A computational study finds that the natural alkaloids lanoginosine and liriodenine bind strongly and stably to the AgrA LytTR domain...
Gut Metabolite 2,8-Dihydroxyquinoline Shields Sperm Cells From Iron-Driven Cell Death
A gut microbiota-derived antioxidant metabolite, 2,8-dihydroxyquinoline, reverses oligoasthenozoospermia in mice by binding the kinase MAPK14 and blocking ferroptotic death of...
Virtual Lab Hunts New Anti-Sickling Drug Candidates for Sickle Cell Disease
Indian researchers used bioisosteric design, docking, ADMET screening, molecular dynamics and DFT calculations to identify two hybrid molecules that bind...
Drug Safety Evidence Has a Shelf Life: Most Harm Findings Expire Within Three Years
A large retrospective cohort study of 505 meta-analyses finds that most early evidence on medication harms expires within about three...
Human Organs on Chips Recreate Body’s Niches to Predict Drug Safety
A Stanford-led review in Nature Biomedical Engineering maps how multi-organ tissue chips that preserve each organ's native niche could transform...
Humble Cucumber Relative Zehneria Emerges as a Pharmacological Powerhouse in Traditional Medicine
A systematic review of 40 studies finds that the medicinal gourd genus Zehneria, especially Zehneria scabra, shows antimicrobial, antiplasmodial, anti-inflammatory,...
AI and Data Mining Take Center Stage in New Wave of Drug Discovery Research
The latest volume of SLAS Discovery showcases how artificial intelligence, deep learning and data-mining strategies are accelerating drug discovery across...
Small Molecules Flip the Switch on a Staphylococcus aureus Protease, Opening a New Antibiotic Avenue
Researchers have identified the first small-molecule activators of the Staphylococcus aureus ClpC/ClpP protease, mapping two druggable regulatory sites that could...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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