Gene GLS May Drive Irritable Bowel Syndrome Risk Through Mannose Metabolism
A combined Mendelian randomization, SMR and mediation analysis links genetically predicted GLS expression to higher irritable bowel syndrome risk, partly...
Gene Variants Tied to Vitamin D Reshape Gut Microbes in Postmenopausal Women
Variants in vitamin D metabolism genes VDR and NADSYN1 are associated with lower gut microbial diversity and altered bacterial abundance...
Groundwater archaea reveal purifying selection and genomic plasticity in CO2-rich aquifer
A metagenomic study of acidic, CO2-rich groundwater reconstructed three thaumarchaeotal Group 1.1c genomes that lacked ammonia-oxidation genes, showed heterotrophic and...
CRISPR Screen Points to Autophagy Blockade Plus PARP Inhibitor Against Lung Cancer
A preclinical CRISPR screen found that loss of mTOR-regulating genes sensitizes small cell lung cancer cells to PARP inhibitors, and...
Curcumin shields rat livers from hydrogen peroxide damage in rat study
In a 50-day rat experiment, oral turmeric extract rich in curcumin reduced hydrogen peroxide-induced liver enzyme elevations, histological damage, and...
Oral clues to a rare keratin disorder: review maps mouth signs to gene mutations
A narrative review of twenty studies finds oral leukokeratosis is the most common oral sign of pachyonychia congenita, most often...
Scientists Link Immune Genes and Iron-Driven Cell Death to PCOS
A new bioinformatics and experimental study identifies twelve candidate genes for polycystic ovary syndrome and shows that the metabolic enzyme...
TDP-43 Overexpression in Human Cells Reproduces Key ALS Pathology and Gene Changes
Scientists built an inducible human cell line that overproduces TDP-43, triggering toxicity, mislocalization, and gene expression changes that overlap with...
New ensemble tool sharpens chromatin interaction calls in 4C-seq data
A weighted-voting ensemble called fourSynergy outperformed individual 4C-seq algorithms in leave-one-group-out cross-validation, reaching a mean F1-score of 0.31 and mean...
Viral RNA contacts leave immune gene promoters accessible yet transcriptionally constrained
A computational reanalysis of public EBV data finds that promoters contacted by the viral EBER noncoding RNAs remain chromatin-accessible yet...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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