Researchers discovered a naturally nuclease-dead miniature CRISPR protein, engineered it into the hypercompact xCas12m, and showed that a single-AAV xCas12m–CRISPRoff...

A graph-based peanut pan-genome built from 14 genomes and resequencing of 2,320 accessions reveals structural variation, identifies flowering and dwarfing...

Kyoto University researchers used adenine base editing to correct the TFG mutation behind HMSN-P, delaying disease onset and extending survival...

A new computational study shows that codon optimality, one of the strongest sequence determinants of messenger RNA half-life, does not...

Researchers in China have engineered a two-plasmid system that combines high cloning efficiency with tight expression control and exceptionally soluble...

The sedge Rhynchospora tenuis completes meiosis and reproduces sexually without chromosomal crossovers, using its holocentric chromosomes to segregate intact parental...

A genus-wide analysis of 60 Isoetes chloroplast genomes shows that AT-biased mutation pressure sets the compositional background while gene-specific selection...

A new time-series transcriptomic study of marine medaka embryos reveals a dual-wave program of zygotic genome activation and a transient...

A new study identifies the mechanosensitive calcium channel TRPV4 as a top candidate driving the inflammatory and remodeling behavior of...

Developmental manganese exposure leaves fruit flies with persistent oxidative stress, DNA fragmentation and protein glycation in adulthood, while early quercetin...