Mitochondrial dysfunction emerges as a shared thread across neurological disease
A new review in Nature Reviews Neurology outlines how mitochondrial biomarkers spanning fluid, genetic, multi-omics and imaging domains could aid...
Progranulin Loss Impairs Cathepsin D Activity and Raises Insoluble TDP-43 in Mouse Brains
A mouse study finds that progranulin deficiency impairs cathepsin D enzymatic activity despite elevated protein levels, disrupts lysosomal organization, and...
Asymmetric Iron Deposits in Basal Ganglia May Signal Early Neurodegeneration
A retrospective SWI MRI review of 35 patients with frontal lesions found paramagnetic deposits restricted to the ipsilateral globus pallidus...
Hypomagnetic Fields Extend Lifespan but Impair Mobility in Parkinson’s Fruit Fly Model
Hypomagnetic fields, defined as magnetic environments far weaker than Earth's natural field, produced a sharply split outcome in a laboratory...
Takahashi wins 2026 prize for iPS cell Parkinson’s therapy
Jun Takahashi received the 2026 Ogawa-Yamanaka Stem Cell Prize for leading an iPS cell-based Parkinson’s disease program that contributed to...
Massive Phosphoproteomics Sweep Maps the Hidden Regulatory Switches on a Key Metabolic Enzyme
An integrative analysis of more than 2,300 human phosphoproteomics datasets identifies serines 168, 169 and 189 as the predominant phosphorylation...
PLOS ONE retracts Syzygium antiparkinsonian study over data integrity concerns
PLOS ONE retracted a Syzygium heyneanum study after editors raised concerns about duplicated-looking images, repetitive table values and the integrity...
Blocking the NAD+-Consuming Enzyme CD38 Protects Neurons and Eases Motor Deficits in a Rat Parkinson’s Model
A selective, brain-penetrant CD38 inhibitor raised NAD+ levels in rodent brain, protected dopaminergic neurons from alpha-synuclein toxicity in vitro, and...
Rotenone-induced Parkinsonism in mice reverses within a year
A 12-month longitudinal study finds that Parkinson-like motor deficits and dopaminergic pathology caused by chronic rotenone exposure in mice fully...
Artemisia compounds show neuroprotective potential in Alzheimer’s models, review finds
A review in 3 Biotech compiles experimental evidence that crude extracts from 17 Artemisia species and artemisinin derivatives show neuroprotective...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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