Acute rapamycin treatment reveals distinct mechanisms of dysfunction in a maternal inflammation mouse model

Subject of Research: Medicine

Article Title: Acute rapamycin treatment reveals distinct mechanisms of dysfunction in a maternal inflammation mouse model

Article References: Le Belle, J., Condro, M. C., Cepeda, C., Oikonomou, K., Tessema, K., Dudley, L., Schoenfield, J., Kawaguchi, R., Geschwind, D., Silva, A., Zhang, Z., Shokat, K., Harris, N., & Kornblum, H. (2026). Acute rapamycin treatment reveals distinct mechanisms of dysfunction in a maternal inflammation mouse model. Nature Communications, 17(1), Article 6386. https://doi.org/10.1038/s41467-026-74958-1

Image Credits: AI Generated

DOI: 10.1038/s41467-026-74958-1

Keywords: acute pharmacological intervention, cellular mechanisms in neurodevelopment, developmental neurobiology, inflammation-induced neurodevelopmental disorders, maternal inflammation mouse model, mechanisms of neural dysfunction, mouse models of maternal immune activation, mTOR signaling pathway, neuroimmune interactions, neuroinflammation effects, rapamycin treatment, therapeutic potential of rapamycin