A distinct CAR-T cell phenotype mediates therapeutic response at limited doses

Subject of Research: Medicine

Article Title: A distinct CAR-T cell phenotype mediates therapeutic response at limited doses

Article References: Yousefian, S., Schubert, M.-L., Minafra, A. R., Derigs, P., Gräßle, S., Horne, A., Demel, U. M., Liebaert, J., Röthemeier, C., Pupp, F., Höpken, U. E., Krönke, J., Busse, A., Keller, U., Schmitt, A., Hübschmann, D., Müller-Tidow, C., Dreger, P., Schmitt, M., & Haas, S. (2026). A distinct CAR-T cell phenotype mediates therapeutic response at limited doses. Nature Communications, 17(1), Article 7589. https://doi.org/10.1038/s41467-026-76068-4

Image Credits: AI Generated

DOI: 10.1038/s41467-026-76068-4

Keywords: cancer immunotherapy mechanisms, CAR-T Cell Therapy, cellular therapy optimization, distinct CAR-T cell phenotypes, dose-dependent CAR-T cell efficacy, immune cell phenotypic profiles, immunotherapy for cancer, Nat Communications cancer research, personalized cancer treatment, T cell engineering, therapeutic response at limited doses