Gut Cancer Gene GLIS3 Found to Fuel Tumors Through a Vitamin B6 Enzyme and Autophagy
Researchers in China have shown that the transcription factor GLIS3 drives gastric cancer progression by binding to the PNPO promoter ...
Tag: xenograft model
Tiny Stem Cell Vesicles Loaded with miR-124 Strike Dual Targets to Curb Colorectal Cancer
Scientists engineered stem cell-derived vesicles to deliver tumor-suppressive miR-124 into colorectal cancer cells, silencing EZH2, weakening STAT3 signaling, and shrinking ...
Patient Tumors Grown From Stem Cells Become Living Test Beds for Duchenne Gene Editing
Researchers converted Duchenne patient stem-cell teratomas into humanized models in which both gene-corrected cell transplants and lipid nanoparticle base editing ...
Enzyme Duo Revealed as Hidden Driver of Ovarian Cancer Growth
Researchers have discovered that the deubiquitinase USP12 stabilizes the Rab GTPase-activating protein TBC1D22A, activating PI3K-AKT-mTOR signaling and driving ovarian cancer ...
Blocking a Calcium Sensor Could Weaken Liver Cancer Cells
New research shows that inhibiting the calcium-sensing receptor with the drug NPS-2143 suppresses the proliferation, migration and invasion of liver ...
Two-Drug Combo Supercharges Liver Cancer Therapy in Preclinical Study
A preclinical study reports that combining the kinase inhibitor regorafenib with the small-molecule PD-1/PD-L1 inhibitor BMS-1 synergistically suppresses the growth, ...
RNA Tagging Enzyme METTL16 Fuels Colorectal Cancer by Hijacking Amino Acid Metabolism and Silencing Immune Cells
New research shows that the RNA methyltransferase METTL16 drives colorectal cancer growth and immune evasion by stabilizing BCAT1 mRNA and ...
Toad Venom Compound Bufalin Blocks Melanoma Growth by Switching Off AKT Signaling
New research shows that bufalin, a steroid from traditional Chinese toad venom, suppresses melanoma growth, metastasis and angiogenesis by reducing ...
Engineered NK Cells Target Hidden Cancer Antigen to Control Melanoma in Mice
Brazilian researchers engineered natural killer cells with a TCR-like CAR that recognizes an intracellular melanoma antigen displayed on HLA molecules, ...
Little-Known Protein EVA1B Emerges as a Hidden Driver of Lung Cancer Spread
New research shows that the little-studied protein EVA1B drives non-small cell lung cancer growth and metastasis through a functional association ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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