Adropin Drives Glycolysis and EMT in Pancreatic Cancer via β₂-AR/β-Arrestin 2/ERK Signaling
A new study shows that the metabolic peptide Adropin promotes glycolytic reprogramming and EMT in pancreatic cancer through β₂-adrenergic receptor, ...
Tag: xenograft model
Long Noncoding RNA KCNMB2-AS1 Drives Clear Cell Renal Cell Carcinoma Growth
Researchers report that the long noncoding RNA KCNMB2-AS1, activated by the transcription factor FOXP3, promotes clear cell renal cell carcinoma ...
New ATG4-targeting peptide blocks autophagy and kills cancer cells in mice
A newly designed cell-penetrating peptide that inhibits the autophagy enzyme ATG4 raised reactive oxygen species and significantly reduced tumor size ...
SIX1 and TEAD1 Team Up to Drive Colorectal Tumor Growth via CTGF
A new study shows the transcription factors SIX1 and TEAD1 synergistically promote colorectal tumor growth by directly co-regulating the CTGF ...
PRRX2-CNTN3 axis drives EMT and metastasis in colorectal cancer
A new Cell Division study reports that the transcription factor PRRX2 activates the CNTN3 gene, promoting epithelial-to-mesenchymal transition, proliferation and ...
Osimertinib and Selinexor Team Up Against Aggressive T-Cell Leukemia in Preclinical Study
A preclinical study reports that the EGFR inhibitor osimertinib and the XPO1 inhibitor selinexor synergistically deplete c-MYC and trigger nucleolar ...
Study reveals how VAV2 fuels glycolysis in esophageal squamous cell carcinoma
A new study reports that the signaling protein VAV2 promotes glycolytic reprogramming and tumor growth in esophageal squamous cell carcinoma ...
Four-Gene Signature Predicts Prostate Cancer Recurrence and Flags SPAG5 as Drug Target
A four-gene transcriptomic signature stratifies prostate cancer patients by biochemical recurrence risk and identifies SPAG5 as a targetable oncogene.
Periplocin Kills Osteosarcoma Cells by Driving Necroptosis and Pyroptosis
A new Biology Direct study shows that periplocin suppresses osteosarcoma cell proliferation and tumor growth in preclinical models by inducing ...
Plant-Derived Nanoparticles From a Medicinal Herb Trigger Ferroptosis in Liver Cancer Models
Nanoscale vesicle-like particles isolated from the medicinal herb Selaginella doederleinii suppressed liver cancer cells and tumors in mice by inducing ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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