AI Variant Scoring Tools Disagree Wildly in Gene-Based Genetic Association Studies
A large-scale UK Biobank study shows that five leading machine learning variant annotation methods produce markedly different calibration, power, and ...
Tag: UK Biobank
Routine Blood Counts Could Reveal Who Carries a Hidden Blood Cancer Risk
A machine learning model called PRISM uses routine complete blood count data to identify adults likely to carry high-risk clonal ...
Simple Blood Ratio Predicts Risk of Cardiovascular-Kidney-Metabolic Syndrome
A new study of over 142,000 people links an inexpensive blood index, the ratio of red blood cell distribution width ...
New Five-Class Obesity Score Predicts 15-Year Heart Risk Better Than BMI
A UK Biobank study of 346,001 adults introduces MetsObesity, a five-tier classification combining waist-to-hip ratio, classic metabolic markers, and inflammation ...
Machine Learning and Proteomics Reveal Why Kidney Injury Turns Chronic
A multi-omics study of over 53,000 UK Biobank participants identifies 25 proteins, including galectin-3, that predict and may drive the ...
Airborne Benzene Linked to Fatty Liver Disease Through Faster Biological Aging
A UK Biobank study of more than 400,000 adults finds that long-term low-level benzene exposure raises the risk of non-alcoholic ...
Reversing Frailty Before It Takes Hold May Shield the Aging Brain From Dementia
A four-cohort study of nearly 16,000 older adults found that progression in frailty raises dementia risk while recovery from pre-frailty ...
Rising Biological Wear-and-Tear Score Tracks Social Disadvantage and Predicts Early Death
A UK Biobank study shows that four-year increases in a composite Biological Health Score are socially patterned and independently predict ...
Social disadvantage may amplify dementia risk in people with type 2 diabetes
A new study in two large national cohorts finds that unfavorable social determinants of health are associated with markedly higher ...
New Family-Trio Genetic Method Exposes Hidden Bias in Causal Gene Studies
A new structural equation modeling framework called FT-SEM uses family trios and parental phenotypes to eliminate dynastic effects in GWAS ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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