Liquid Droplets Inside Cancer Cells Explain Why a Leukemia Drug Works So Slowly
A new Cell Research study shows that BCR-ABL1 forms liquid-like phase-separated condensates inside leukemic cells that physically slow tyrosine kinase ...
Tag: Tyrosine kinase inhibitors
When Tumors Return May Predict Survival in Metastatic GIST
A large Japanese multicenter cohort study finds that patients with metastatic gastrointestinal stromal tumors survive significantly longer when metastases appear ...
RNA Profiling Splits Deadly Dog Spleen Cancer into Three Actionable Subtypes
Researchers at the University of São Paulo used a qPCR-based gene expression panel to divide canine splenic hemangiosarcoma into three ...
From Cabozantinib to Zanzalintinib: Chemical Tweaks Open New Frontier in Product Hopping
For decades, the pharmaceutical industry’s most familiar strategy for extending the commercial life of a successful medicine has been to ...
Anlotinib Drives Hepatoblastoma Resistance via GAD1/GABA
Intrinsic drug resistance remains one of the formidable challenges in cancer therapy, often thwarting the efficacy of promising treatments and ...
Tyrosine Kinase and PD-1 Inhibitors Boost Liver Cancer Treatment
In a groundbreaking study poised to reshape therapeutic strategies for hepatocellular carcinoma (HCC), researchers have demonstrated the superior efficacy and ...
Tyrosine Kinase Inhibitors Combat Ewing’s Sarcoma
Ewing’s sarcoma (ES) stands as one of the most aggressive primary bone malignancies, predominantly afflicting children and adolescents. This rare ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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