The Tumor Suppressor CYLD: A Molecular Switchboard Controlled by Chemical Tags
A new review reveals how the tumor suppressor and deubiquitinating enzyme CYLD is switched on and off by phosphorylation, ubiquitination, ...
Tag: tumor suppressor genes
Cell-free DNA methylation markers emerge as promising liquid biopsy tools for detecting hepatitis B-related liver cancer
A new review highlights how cell-free DNA methylation markers, shaped in part by hepatitis B virus-driven epigenetic changes, could transform ...
Early NOTCH1 Mutation Shields Esophageal Tissue from Turning Cancerous
A new evolutionary analysis shows that NOTCH1 mutations flourish in normal esophageal tissue but epistatically suppress the later driver mutations, ...
Cancer Gene Mutations Awaken the Immune System in Early Oral Cancer
Researchers at Tokushima University found that combined TP53 and CDKN2A mutations activate cGAS–STING-mediated antitumor immunity, delaying progression to invasive oral ...
Hidden Genome Folds Silence Two Tumor-Suppressing Genes in Aggressive Breast Cancer
Researchers have discovered that DNA methylation evicts the architectural protein CTCF from the HOXD locus, collapsing a chromatin loop that ...
RUNX3 Emerges as a Master Switch Behind Cancer Chemoresistance
A new review in Cancer Cell International details how the tumor suppressor RUNX3 regulates apoptosis, drug efflux, cell cycle control, ...
CRISPR Methylation Editing Rewrites the Cancer Epigenome Toward Causation
A new review argues that CRISPR-based DNA methylation editing can transform cancer epigenetics from a correlative science into a causal ...
New Study Uncovers Key Genes That Suppress Blood Cancer Progression
In a groundbreaking discovery that could reshape the landscape of lymphoma treatment, Australian scientists have unveiled a critical cellular mechanism ...
Pan-Cancer Study Reveals DNA Repair Defects
In a groundbreaking study poised to reshape the landscape of precision oncology, researchers have conducted the largest pan-cancer analysis focusing ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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