Immune Therapy Plus Chemotherapy Erases Stage IIIB Lung Tumor Before Surgery
A stage IIIB lung squamous cell carcinoma patient achieved a pathological complete response after neoadjuvant sugemalimab plus chemotherapy, with biomarker ...
Tag: tumor mutational burden
Cholesterol-Hungry Immune Cells May Decide Survival in Head and Neck Cancer
A multi-omics study finds that LDL cholesterol metabolism reshapes macrophages and tumor cells in head and neck squamous cell carcinoma, ...
Liquid Biopsy Guides First-of-Its-Kind Immunotherapy Win in Relapsed Lymphoma
A high tumor mutational burden detected by liquid biopsy guided nivolumab treatment that produced a durable complete remission in a ...
Rare POLE P286R-Mutated Lung Cancer Shows Dramatic Response to Immunotherapy
A case report describes the first hepatoid adenocarcinoma of the lung harboring a POLE P286R mutation, which drove hypermutation, mismatch ...
Machine Learning Model Predicts Which Lung Cancer Patients Will Respond to Immunotherapy
Researchers developed a random forest model integrating six clinical, inflammatory and molecular predictors that forecasts immunotherapy response in advanced lung ...
Gene Amplifications, Not Mutation Load, Mark Poor Survival in Aggressive Bladder Cancer
A Swiss genomic study of muscle-invasive bladder cancer finds that oncogene amplifications, rather than tumor mutational burden or microsatellite instability, ...
Chemoradiotherapy May Unlock Immunotherapy in Hard-to-Treat Rectal Cancer
A new review argues that neoadjuvant chemoradiotherapy may induce immune checkpoint blockade responsiveness in mismatch repair-proficient rectal cancer, with sequential ...
Blood Test and Tumor Genetics Sharpen Predictions of Rectal Cancer Immunotherapy Success
New TORCH trial data show that combining SMAD4 mutation status, tumor mutational burden, and serial ctDNA with MRI assessments substantially ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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