Dual Immunotherapy Clues Reveal How to Wake the Immune System Against Glioblastoma
Two UCLA-led studies identify T-cell infiltration as the key to effective glioblastoma immunotherapy and introduce a preclinical model that recreates ...
Tag: tumor microenvironment
Single-cell map shows how pancreatic cancer clones evolve to outsmart treatment
A single-cell analysis of nearly half a million cells from pancreatic tumors reveals how evolving clones reshape their DNA to ...
Smart Nanoparticles Light Up Cervical Cancer and Strike It With Two Weapons at Once
Researchers have engineered manganese dioxide nanocarriers that degrade inside the tumor microenvironment to release methotrexate and activate DNAzyme probes, achieving ...
Hidden RNA Switches: New Tool Reveals lncRNAs That Define Tumor-Fighting T Cells
A new computational framework called SDSGI uncovers subtype-specific long non-coding RNAs in tumor-infiltrating CD8-positive T cells across multiple cancer types, ...
Immune Molecule B7-H3 Drives Triple-Negative Breast Cancer Through a Hidden Protein Machinery
New research reveals that the immune checkpoint protein B7-H3 fuels triple-negative breast cancer from within by sustaining SP1-dependent HSPA8 chaperone ...
KRAS-mutant tumors flood themselves with adenosine to blind immune cells
Researchers report that oncogenic KRAS reprograms adenosine metabolism through NT5E upregulation and ADA suppression, creating an immunosuppressive tumor microenvironment that ...
Chromatin Architect Satb1 Reveals a Switch That Disarms Tumor-Protective Immune Cells
New research shows the chromatin organizer Satb1 enables regulatory T cells to promote tumor growth while remaining dispensable for preventing ...
Blocking FGFR Signaling Supercharges Immunotherapy in Hard-to-Treat Colorectal Cancer
New research shows that inhibiting the FGFR signaling pathway reduces T cell exhaustion and repolarizes macrophages, significantly enhancing PD-1 blockade ...
New AI Model Decodes the Signals That Guide Immune Cells Into Tumors
Researchers at MD Anderson developed an AI tool called SPACER that decodes the spatial signals attracting or repelling immune cells ...
Cancer Gene Mutations Awaken the Immune System in Early Oral Cancer
Researchers at Tokushima University found that combined TP53 and CDKN2A mutations activate cGAS–STING-mediated antitumor immunity, delaying progression to invasive oral ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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