PLA2G2A fuels gallbladder cancer stemness and immune suppression
A new Cellular Oncology study shows that the enzyme PLA2G2A drives gallbladder cancer progression by promoting cancer stemness through PLA2R1, ...
Tag: tumor microenvironment
CREBBP mutation drives lymphoma growth and T-cell exhaustion via NOTCH pathway
A new study reports that the recurrent CREBBP Y1503C mutation promotes diffuse large B-cell lymphoma growth and CD8+ T-cell dysfunction ...
AI Reads Bladder Cancer Slides and Pinpoints RTN3 Behind Chemotherapy Resistance
A multimodal AI model built from routine pathology slides predicts bladder cancer survival and led researchers to RTN3, which drives ...
Two-pronged antibody depletes suppressive T cells and boosts antitumor immunity in mice
A new bispecific antibody targeting CCR8 and CD3 shrank breast, lung and colon tumors in mice and was well tolerated ...
CAR-NK Cells Move From Concept Toward Clinic as Review Maps Engineering Fixes
A new review synthesizes engineering strategies and early clinical findings for CAR-NK cell immunotherapy in blood cancers and solid tumors.
Cysteine Cathepsins Mapped Across Breast Tumors Reveal States That May Shape Antibody-Drug Conjugate Use
A single-cell and spatial atlas of 66 breast tumors shows cysteine cathepsins occupy specific immune, epithelial and stromal niches, and ...
Bibliometric Analysis Maps a Decade of MDSC Research in the Tumor Microenvironment
A bibliometric analysis of 5,967 publications maps a decade of MDSC research, identifying leading countries, institutions, authors, and emerging research ...
CAR-T Therapy for Brain Tumors Shows Early Promise and Persistent Barriers
A conference correspondence summarizing 12 clinical and translational abstracts on next-generation CAR-T therapy for malignant brain tumors, reporting early feasibility ...
Disease Microenvironments May Reshape the Safety of Near-Infrared Theranostic Nanomaterials, Review Finds
A new review argues that tumor acidity, hypoxia, reactive oxygen species and microbial cues can fundamentally alter the degradation, activation ...
Research report: POSTN+ tumor-associated endothelial cells promote and predict pulmonary metastasis in osteosarcoma
Researchers identified a POSTN-expressing tumor-associated endothelial cell subset that promotes and predicts pulmonary metastasis in osteosarcoma.
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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