FAPI-Conjugated Nanoparticles Show Promise for Targeted Cancer Imaging and Therapy
A systematic review finds that nanoparticles conjugated with fibroblast activation protein inhibitors show strong preclinical promise for targeted cancer imaging ...
Tag: tumor microenvironment targeting
Genetic Switch Lets CAR-T Cells Turn Themselves On and Off Inside Tumours
Scientists at the Italian Institute of Technology in Naples have engineered CAR-T cells with a synthetic genetic switch that activates ...
The Hidden Architects of Colorectal Cancer: How Fibroblasts Drive Treatment Failure
A new review in Cancer Cell International details how cancer-associated fibroblasts remodel the colorectal tumor microenvironment and drive resistance to ...
Self-Reporting Nanoparticle Turns Tumor Hypoxia Into a Weapon Against Cancer
Researchers have created a chemiluminescent nanoparticle that amplifies tumor hypoxia with light, releases a chemotherapy drug in response, and glows ...
Collagen Scaffold Helps Starved Tumours Switch Fuel and Evade Treatment
University of Sheffield researchers found that type I collagen in tumour scaffolding lets breast and pancreatic cancer cells switch fuel ...
Mogrosides regulate tumor metabolism and immune response, revealing dual anticancer mechanism
The monk fruit, a small green gourd native to the mountainous forests of Guangxi province in southern China, has been ...
New strategy strengthens CAR-T cells against solid tumors, potentially transforming cancer treatment
For years, CAR-T cell therapy has stood as one of cancer medicine’s most striking successes. By removing a patient’s T ...
Targeting a signaling pathway activated by acidic tumor environment restores treatment response to PARP inhibitors in ovarian cancer
PARP inhibitors are among the most widely used therapies for ovarian cancer, but their long-term effectiveness is limited by acquired resistance Researchers ...
Study Finds Casdatifan Produces Durable Tumor Responses in Advanced Kidney Cancer
A new multi-center Phase 1 study is testing casdatifan, an investigational oral therapy designed to inhibit hypoxia-inducible factor-2 alpha (HIF-2α), ...
Radiopharmaceutical Therapy Targeting FAP Demonstrates Wide-Ranging Efficacy Across Various Cancer Types
A groundbreaking advancement in cancer treatment has emerged with the development of novel radiopharmaceutical therapies targeting fibroblast activation protein (FAP), ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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