Tumors in the Same Dog Are Molecularly Worlds Apart, Landmark Study Shows
A new transcriptomic study of 179 canine mammary tumors shows that synchronous tumors within the same dog are molecularly heterogeneous ...
Tag: tumor heterogeneity
Massive Single-Cell Atlas Maps Five Cancer Archetypes in Multiple Myeloma
A single-cell atlas of 341 multiple myeloma patients identifies five malignant transcriptional archetypes and an orthogonal proliferative program, enabling improved ...
New AI Framework SCIGMA Unifies Spatial Multiomics Data With Built-In Uncertainty Estimates
Researchers at Brown University have developed SCIGMA, a deep learning framework that integrates up to five spatial omics modalities across ...
Scientists Build a Gene-Based Survival Model for Lung Cancer Using a Newly Defined Cell Death Pathway
Researchers constructed a fourteen-gene triaptosis-related prognostic model for lung adenocarcinoma using transcriptomic analysis, machine learning, single-cell sequencing, and experimental validation.
New Nectin-4-Targeted PET Scan Outperforms FDG in Aggressive Breast Cancer
A new gallium-68 tracer targeting Nectin-4 detected more lesions and predicted survival better than FDG PET/CT in patients with recurrent ...
Single-Cell Multi-Omics Reveals How Cancer Clones Evolve Genotype and Phenotype Together
A Nature Reviews Cancer review explains how genotype-aware single-cell multi-omics and phylogenetic reconstruction are revealing how mutant clones in healthy ...
Early Treatment Attrition After Recurrence Following Neoadjuvant Chemo-Immunotherapy in Triple-Negative Breast Cancer
Triple-negative breast cancer is sending researchers back to a difficult question: what happens when an aggressive tumor returns after receiving ...
Spatial Transcriptomics Reveals Histology-Linked Growth Patterns in Colorectal Liver Metastases
A new study is turning the microscopic “how it grows” question in colorectal cancer liver metastases into a measurable molecular ...
New Drug Design Method Enhances Cancer Treatments with Increased Potency
A new strategy for precision cancer therapy could make antibody-drug conjugates (ADCs) far more potent against heterogeneous tumors. Modern ADCs ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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