LIG1 Loss Reveals Targetable Weakness Against Chemotherapy-Resistant Triple-Negative Breast Cancer
In triple-negative breast cancer (TNBC) that carries TP53 mutations, loss of one copy of the DNA ligase I gene (LIG1) ...
Tag: triple-negative breast cancer
Single-Cell Multi-Omics Reveals Cancer-Associated Fibroblast Programs in Breast Cancer
A groundbreaking study has unveiled new insights into the complex biology of cancer-associated fibroblasts (CAFs) within triple-negative breast cancer (TNBC), ...
Olaparib Benefits HR-Deficient TNBC and Platinum-Sensitive Ovarian Cancers
In a groundbreaking phase 2 clinical trial, researchers have demonstrated the efficacy of olaparib, a PARP inhibitor, in treating metastatic ...
BET inhibition reveals glycolytic vulnerability via HIF1α in triple-negative breast cancer
In a groundbreaking study poised to reshape the therapeutic landscape of aggressive breast cancers, researchers have uncovered a novel metabolic ...
Sphingolipid Metabolism: A Target in Triple-Negative Breast Cancer
In a groundbreaking study published in the Journal of Translational Medicine, researchers Li, Chen, and Wang lead an exploration into ...
Uncovering a Crucial Cellular Mechanism Behind Breast Cancer Relapse
Triple-negative breast cancer (TNBC) remains one of the most formidable challenges in oncology due to its aggressive nature and its ...
Exogenous Cystine Influences Glutamine Dependence in TNBC
In a groundbreaking study unveiled recently, researchers have illuminated the complex metabolic dependencies underpinning triple-negative breast cancer (TNBC), highlighting a ...
Restoring Order in Dividing Cancer Cells Could Halt Metastasis, Study Finds
Triple-negative breast cancer (TNBC) is notorious for its aggressive nature and resistance to conventional therapies, creating an urgent need for ...
New Study from Sun Yat-Sen University Reveals Circular RNA-Encoded Protein SCAP-129aa Promotes Platinum Resistance in Triple-Negative Breast Cancer
Triple-negative breast cancer (TNBC) remains one of the most challenging subtypes of breast cancer to treat effectively. Defined by the ...
Whole Exome Sequencing Links FANCM to ER-Negative Breast Cancer
In a groundbreaking study published in Nature Communications, researchers have revealed a crucial genetic link that increases susceptibility to a ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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