L-carnitine attenuates trastuzumab-induced changes in cardiac H9c2 cells
A laboratory study found that L-carnitine attenuated selected signaling, biochemical and viability changes induced by trastuzumab in cardiac H9c2 cells.
Tag: trastuzumab
NEK2 Drives Trastuzumab Resistance in Gastric Cancer Through m6A Control of FN1
New research reveals that the kinase NEK2 promotes trastuzumab resistance in gastric cancer by boosting WTAP/YTHDF1-dependent m6A modification of FN1 ...
Biosimilars Cut Cancer Drug Costs by Nearly $4,000 a Month for Insurers, UCLA Study Shows
A UCLA-led analysis of more than 14,000 patient-drug pairs published in JAMA Oncology found that exclusive biosimilar use was associated ...
Pill-Based HER2 Blocker Matches Standard Antibody Duo in Early Breast Cancer Trial
A multicenter phase II trial found that a pyrotinib-based neoadjuvant regimen achieved pathological response rates comparable to the standard trastuzumab-pertuzumab ...
Landmark Trial Pinpoints Which HER2-Positive Breast Cancers Respond to Shorter, Gentler Chemotherapy
Secondary results from the ECOG-ACRIN CompassHER2-pCR trial identify clinical and molecular factors, including HER2DX genomic scores, that predict which stage ...
Exercise May Not Shield the Heart From Breast Cancer Drugs, Review Finds
A new systematic review and meta-analysis of randomized trials finds that current evidence does not confirm a consistent cardioprotective effect ...
Scientists Turn Complement Footprints Into a Second Strike Against Drug-Resistant Cancer Cells
Researchers engineered an anti-C4d antibody that targets complement fragments left on tumor cells that survived antibody therapy, boosting complement-mediated killing ...
Breast Tumors Shed Their HER2 Target in More Than Half of Cases After Drug Therapy
A new MD Anderson study finds that 57 percent of residual breast tumors lose HER2 overexpression after HER2-targeted neoadjuvant therapy, ...
Biosimilar Trastuzumab EG12014 Matches Original Drug in Phase III Breast Cancer Trial
A Phase III trial of 807 patients found the trastuzumab biosimilar EG12014 statistically equivalent to reference trastuzumab in efficacy, safety, ...
Liposomal Paclitaxel With HER-2 Blockers Shows Strong Real-World Results in Advanced Breast Cancer
A real-world study of 526 patients found that paclitaxel liposome combined with anti-HER-2 targeted therapies delivered median overall survival of ...
-
Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
-
University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
-
Bee body mass, pathogens and local climate influence heat tolerance
-
Researchers record first-ever images and data of a shark experiencing a boat strike
-
Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
Embark on a thrilling journey of discovery with Scienmag.com—your ultimate source for cutting-edge breakthroughs. Immerse yourself in a world where curiosity knows no limits and tomorrow’s possibilities become today’s reality!